About: Enveloped Virus but not Bacteria Block IL‐13 Responses in Human Cord Blood T Cells In Vitro

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enveloped Virus but not Bacteria Block IL‐13 Responses in Human Cord Blood T Cells In Vitro
Creator	Svensson, A Bergström, T Eriksson, K Nordström, I Rudin, A
Source	Medline; PMC
abstract	Infections that occur early in life may have a beneficial effect on the immune system and thereby reduce the risk of allergen sensitization and/or allergic disease. It is not yet clear to what extent specific virus and/or bacteria can mediate this effect. The purpose of this study was to assess the role of virus and bacteria in CD4(+) T cell‐derived cytokine production in newborns. We compared the effects of five bacteria (Staphlococcus aureus, Escherichia coli, Clostridium difficile, Lactobacillus rhamnosus and Bifidobacterium bifidus) and seven virus (adenovirus, coronavirus, cytomegalovirus, herpes simplex virus, influenza virus, morbillivirus and poliovirus) on the Th1/Th2 cytokine production in mixed lymphocyte reactions using CD4(+) T cells from cord blood cocultured with allogenic myeloid or plasmacytoid dendritic cells. When comparing the baseline cytokine production prior to microbial stimulation, we observed that cord plasmacytoid DC were stronger inducers of Th2 cytokines (IL‐5 and IL‐13) compared with cord myeloid DC and to adult DC. When adding microbes to these cultures, bacteria and virus differed in two major respects; Firstly, all enveloped viruses, but none of the bacteria, blocked Th2 (IL‐13) production by cord CD4(+) cells. Secondly, all Gram‐positive bacteria, but none of the virus, induced IL‐12p40 responses, but the IL‐12p40 responses did not affect Th1 cytokine production (IFN‐γ). Instead, Th1 responses were correlated with the capacity to induce IFN‐α secretion, which in cord cells were induced by S. aureus and influenza virus alone. These data imply that enveloped virus can deviate Th2 responses in human cord T cells.
has issue date	2012-03-16(xsd:dateTime)
bibo:doi	10.1111/j.1365-3083.2012.02676.x
bibo:pmid	22229804
has license	no-cc
sha1sum (hex)	5cb1ec7be016bfadb9ca5187b2af593320fb8518
schema:url	https://doi.org/10.1111/j.1365-3083.2012.02676.x
resource representing a document's title	Enveloped Virus but not Bacteria Block IL‐13 Responses in Human Cord Blood T Cells In Vitro
has PubMed Central identifier	PMC7190188
has PubMed identifier	22229804
schema:publication	Scand J Immunol
resource representing a document's body	covid:5cb1ec7be016bfadb9ca5187b2af593320fb8518#body_text
is schema:about of	named entity 'Responses' named entity 'Blood' named entity 'IL-13' named entity 'morbillivirus' named entity 'IFN' named entity 'Virus' named entity 'virus' named entity 'allogenic' named entity 'secretion' named entity 'pDC' named entity 'regulatory T cells' named entity 'Th2' named entity 'CD4 +' named entity 'citrate' named entity 'IL-13' named entity 'BD Biosciences' named entity 'Th2' named entity 'IL-12' named entity 'IL-13' named entity 'neonatal' named entity 'IFN-a' named entity 'IFN' named entity 'IL-13' named entity 'TSST-1' named entity 'HHV-6' named entity 'allergies' named entity 'microbe' named entity 'CD4 +' named entity 'cytokine' named entity 'Th1' named entity 'HSV' named entity 'R&D' named entity 'Staphlococcus aureus' named entity 'allergic sensitization' named entity 'pDC' named entity 'cytokine' named entity 'APC' named entity 'pDC' named entity 'adenovirus' named entity 'commensal' named entity 'Cord blood' named entity 'IFN' named entity 'cord blood' named entity 'IL-2' named entity 'cytokines' named entity 'viruses' named entity 'human herpes virus' named entity 'IFN' named entity 'pDC' named entity 'UV-light' named entity 'viruses' named entity 'IL-12 p40' named entity 'IL-5' named entity 'pDC' named entity 'microbes' named entity 'IFN' named entity 'MLR' named entity 'detection limit' named entity 'biologically active' named entity 'IFN-a' named entity 'Uppsala' named entity 'microbe' named entity 'hIFN' named entity 'coronavirus' named entity 'enveloped viruses' named entity 'allogenic' named entity 'Sweden' named entity 'statistically significant' named entity 'Th2' named entity 'viruses' named entity 'IL-13' named entity 'Th2' named entity 'IL-5' named entity 'CD4 +' named entity '0.04%' named entity 'staphylococcus' named entity 'Sigma-Aldrich'

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