About: Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43()

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43()
Creator	Haupt, Thomas Haynes, Lia Miao, Congrong Anderson, Larry Blanchard, Elisabeth
Source	Elsevier; Medline; PMC
abstract	Human coronaviruses are one of the main causes of upper respiratory tract infections in humans. While more often responsible for mild illness, they have been associated with illnesses that require hospitalization. In this study, an assay for one of the human coronaviruses, OC43, was developed using a truncated recombinant nucleocapsid (N) protein antigen in an enzyme immunosorbent assay (ELISA) and evaluated using serum collected from HCoV-OC43-infected patients, healthy adults, and patients with other respiratory virus infections. Results showed that the diagnostic sensitivity and specificity of the assay were 90.9% (10/11) and 82.9% (39/47), respectively. To evaluate the clinical utility of the ELISA, serum samples collected from patients during an outbreak of HCoV-OC43 infection and previously identified as positive by HCoV-OC43 whole N ELISA were screened resulting in 100% diagnosis agreement between the testing methods. These results suggest that this assay offers a reliable method to detect HCoV-OC43 infection and may be a useful tool in coronavirus seroepidemiological studies.
has issue date	2011-07-21(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2011.07.005
bibo:pmid	21801752
has license	no-cc
sha1sum (hex)	5ce0d13e42d2e7355eef45094d651151d2fc2deb
schema:url	https://doi.org/10.1016/j.jviromet.2011.07.005
resource representing a document's title	Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43()
has PubMed Central identifier	PMC7112803
has PubMed identifier	21801752
schema:publication	J Virol Methods
resource representing a document's body	covid:5ce0d13e42d2e7355eef45094d651151d2fc2deb#body_text
is schema:about of	named entity 'MILD' named entity 'THESE' named entity 'TOOL' named entity 'PREVIOUSLY' named entity 'METHOD' named entity '100%' named entity 'STUDY' named entity 'RESPIRATORY VIRUS' named entity 'ASSOCIATED WITH' named entity 'CLINICAL UTILITY' named entity 'PATIENTS' named entity 'SAMPLES' named entity 'EVALUATE' named entity 'EVALUATED' named entity 'NUCLEOCAPSID PROTEIN' named entity 'HUMAN' named entity 'CORONAVIRUSES' named entity 'INFECTED' named entity 'NUCLEOCAPSID' named entity 'OC43' named entity 'MAY BE A' named entity 'POSITIVE' named entity 'PROTEIN ANTIGEN' named entity 'INFECTIONS' named entity 'UPPER RESPIRATORY TRACT INFECTIONS' named entity 'SENSITIVITY AND SPECIFICITY' named entity 'OUTBREAK' named entity 'DIAGNOSIS' named entity 'TO DETECT' named entity 'RECOMBINANT' named entity 'BASED' named entity 'HAVE' named entity 'CORONAVIRUS' named entity 'MORE OFTEN' named entity 'ELISA' named entity 'HOSPITALIZATION' named entity 'SEROEPIDEMIOLOGICAL STUDIES' named entity 'RESULTING IN' named entity 'HEALTHY' named entity 'SUGGEST' named entity 'RESULTS' named entity 'ILLNESS' named entity 'COLLECTED' named entity 'ONE OF' named entity 'CAUSES' named entity 'ENZYME' named entity 'PROTEIN ' named entity 'DETECTION' named entity 'HUMAN CORONAVIRUS OC43' named entity 'DEVELOPMENT' named entity 'AGREEMENT' named entity 'ASSAY' named entity 'HCOV-OC43' named entity 'USING' named entity 'ADULTS' named entity 'RELIABLE' named entity 'IMMUNOSORBENT' named entity 'IDENTIFIED' named entity 'TESTING METHODS' named entity 'USEFUL' named entity 'HUMANS' named entity 'DIAGNOSTIC SENSITIVITY' named entity 'MAIN' named entity 'INFECTION' named entity 'TRUNCATED' named entity 'IMMUNOASSAY' named entity 'SERUM' named entity 'RESPONSIBLE' named entity 'TRUNCATED' named entity 'RECOMBINANT' named entity 'ANTIBODIES' covid:arg/5ce0d13e42d2e7355eef45094d651151d2fc2deb named entity 'serum' named entity 'upper respiratory tract infections' named entity 'nucleocapsid' named entity 'collected' named entity 'diagnosis'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software