About: Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids
Creator	Aquino, Cecilia Bayona, Andrea Castano, Enrique Guillen-Chable, Francisco Hozak, Pavel Pereira-Santana, Alejandro Vitale, Nicolas Carlos Rodríguez-Zapata, Luis Corona, Ulises
Source	Medline; PMC
abstract	Fibrillarin is a highly conserved nucleolar methyltransferase responsible for ribosomal RNA methylation across evolution from Archaea to humans. It has been reported that fibrillarin is involved in the methylation of histone H2A in nucleoli and other processes, including viral progression, cellular stress, nuclear shape, and cell cycle progression. We show that fibrillarin has an additional activity as a ribonuclease. The activity is affected by phosphoinositides and phosphatidic acid and insensitive to ribonuclease inhibitors. Furthermore, the presence of phosphatidic acid releases the fibrillarin-U3 snoRNA complex. We show that the ribonuclease activity localizes to the GAR (glycine/arginine-rich) domain conserved in a small group of RNA interacting proteins. The introduction of the GAR domain occurred in evolution in the transition from archaea to eukaryotic cells. The interaction of this domain with phospholipids may allow a phase separation of this protein in nucleoli.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.3390/cells9051143
bibo:pmid	32384686
has license	cc-by
sha1sum (hex)	5d23de80782528ba11b763f4c9f322580c923758
schema:url	https://doi.org/10.3390/cells9051143
resource representing a document's title	Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids
has PubMed Central identifier	PMC7290794
has PubMed identifier	32384686
schema:publication	Cells
resource representing a document's body	covid:5d23de80782528ba11b763f4c9f322580c923758#body_text
is schema:about of	named entity 'proteins' named entity 'progression' named entity 'conserved' named entity 'acid' named entity 'shape' named entity 'The activity' named entity 'eukaryotic cells' named entity 'interaction' named entity 'Dependent' named entity 'ADDITIONAL' named entity 'INTERACTING' named entity 'PROTEIN ' named entity 'REPORTED' named entity 'EVOLUTION' named entity 'fibrillarin' named entity 'phosphoinositides' named entity 'nucleolar' named entity 'phase separation' named entity 'domain' named entity 'nuclear' named entity 'highly' named entity 'methyltransferase' named entity 'interacting proteins' named entity 'nucleoli' named entity 'fibrillarin' named entity 'methyltransferase' named entity 'Fibrillarin' named entity 'methylation' named entity 'fibrillarin' named entity 'glycine' named entity 'localizes' named entity 'Wetzlar' named entity 'primer' named entity 'fibrillarin' named entity 'TRITC' named entity 'ROI' named entity 'non-coding RNA' named entity 'rDNA' named entity '6xHis' named entity 'Nop56' named entity 'fibrillarin' named entity 'rRNA' named entity 'ribonuclease' named entity 'ribonuclease' named entity 'phospholipid' named entity 'NaCl' named entity 'rRNA' named entity 'polymerization' named entity 'arginine' named entity 'mutation' named entity 'interact' named entity '28S rRNA' named entity 'RNA' named entity 'arginine' named entity 'DMEM' named entity 'Tris-HCl' named entity 'fibrillarin' named entity 'fibrillarin' named entity 'N-terminal' named entity 'photobleaching' named entity 'ribonucleoprotein complex' named entity 'fibrillarin' named entity 'mutation' named entity 'phenotypes' named entity 'phospholipid' named entity 'diffusion coefficient' named entity 'ribosomal genes' named entity 'IBV' named entity 'Nco' named entity 'ribonuclease' named entity 'fibrillarin' named entity 'Germany' named entity 'Nop58'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software