About: Severe COVID-19: NLRP3 Inflammasome Dysregulated

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Severe COVID-19: NLRP3 Inflammasome Dysregulated
Creator	Kalergis, Alexis Mcauley, Julie Sutterwala, Fayyaz Te Velde, Anje Van Den Berg, Daan
source	Medline; PMC
abstract	SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous adjuvant activity necessary to mount a proper adaptive immune response against the virus. Heterogeneous response of COVID-19 patients could be attributed to differences in not being able to properly downregulate NLRP3 inflammasome activation. This relates to the fitness of the immune system of the individual challenged by the virus. Patients with a reduced immune fitness can demonstrate a dysregulated NLRP3 inflammasome activity resulting in severe COVID-19 with tissue damage and a cytokine storm. We sketch the outlines of five possible scenarios for COVID-19 in medical practice and provide potential treatment options targeting dysregulated endogenous adjuvant activity in severe COVID-19 patients.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01580
bibo:pmid	32670297
has license	cc-by
sha1sum (hex)	5d5c58c30a83fb022c9e007572ac2e7648c44ea3
schema:url	https://doi.org/10.3389/fimmu.2020.01580
resource representing a document's title	Severe COVID-19: NLRP3 Inflammasome Dysregulated
has PubMed Central identifier	PMC7332883
has PubMed identifier	32670297
schema:publication	Front Immunol
resource representing a document's body	covid:5d5c58c30a83fb022c9e007572ac2e7648c44ea3#body_text
is schema:about of	named entity 'MINI' named entity 'NLRP3' named entity 'inflammasome' named entity 'inflammaging' named entity 'NLRP3' named entity 'IL-18' named entity 'capillary' named entity 'inflammasome' named entity 'HMGB1' named entity 'endogenous' named entity 'viral load' named entity 'NLRP3' named entity 'infection' named entity 'clinical study' named entity 'cGAS' named entity 'antibacterial' named entity 'NLRP3' named entity 'NK cells' named entity 'inflammasome' named entity 'inflammasome' named entity 'colchicine' named entity 'NLRP3' named entity 'inflammatory response' named entity 'IL-1β' named entity 'immune defense' named entity 'clinical trial' named entity 'NF-κB' named entity 'pyroptosis' named entity 'medical practice' named entity 'endogenous' named entity 'endogenous' named entity 'Pyrin' named entity 'neutrophil' named entity 'pyroptosis' named entity 'organ dysfunction' named entity 'HMGB1' named entity 'immune response' named entity 'Wuhan' named entity 'pyroptosis' named entity 'protein' named entity 'COVID-19' named entity 'co-stimulatory' named entity 'cell death' named entity 'NLRP3' named entity 'High mobility group' named entity 'NLRP3' named entity 'NLRP3' named entity 'endogenous' named entity 'SARS-CoV-2' named entity 'morbidity' named entity 'GM-CSF' named entity 'non-specific' named entity 'IFN-γ' named entity 'microRNA' named entity 'downstream pathways' named entity 'NLRP3' named entity 'high levels' named entity 'SARS-CoV-2' named entity 'traditional Chinese medicine' named entity 'lidocaine' named entity 'Th17' named entity 'antibody' named entity 'POP1' named entity 'cytokine' named entity 'adjuvant' named entity 'danger signals' named entity 'NLRP3' named entity 'immune response' named entity 'virus' named entity 'Pneumonia' named entity 'downregulated' named entity 'macrophages' named entity 'diminished capacity' named entity 'CD80' named entity 'inflammation of the lungs' named entity 'endothelial' named entity 'virus'

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