About: Glycyrrhizin inhibits influenza A virus uptake into the cell

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycyrrhizin inhibits influenza A virus uptake into the cell
Creator	Bachhofner, Nicole Kurz, Harald Wolkerstorfer, Andrea Szolar, Oliver
Source	Elsevier; Medline; PMC
abstract	Abstract We investigated the mechanism by which glycyrrhizin (GL), the main active component of licorice roots, protects cells from infection with influenza A virus (IAV). We found that GL treatment leads to a clear reduction in the number of IAV-infected human lung cells as well as a reduction in the CCID50 titer by 90%. The antiviral effect, however, was limited to one or two virus replication cycles. Analysis of different GL treatment protocols suggested that the antiviral effect of GL was limited to an early step in the virus replication cycle. A direct inhibitory action of GL on IAV particles could be excluded and GL did not interact with virus receptor binding either. The antiviral effect of GL was abolished by treatment 1h after virus infection, whereas pre-treatment and treatment during and after virus adsorption led to a reduction in the cytopathic effect, reduced viral RNA within the cells and in the cell supernatants, and reduced viral hemagglutination titers. Detailed virus uptake analyses unambiguously demonstrated reduced virus uptake in various GL-treated cells. These observations lead to the conclusion, that the antiviral activity of GL is mediated by an interaction with the cell membrane which most likely results in reduced endocytotic activity and hence reduced virus uptake. These insights might help in the design of structurally related compounds leading to potent anti-influenza therapeutics.
has issue date	2009-08-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2009.04.012
bibo:pmid	19416738
has license	els-covid
sha1sum (hex)	5d80f69f6ea60aef7c258bcab7dd4b997c19c24d
schema:url	https://doi.org/10.1016/j.antiviral.2009.04.012
resource representing a document's title	Glycyrrhizin inhibits influenza A virus uptake into the cell
has PubMed Central identifier	PMC7126985
has PubMed identifier	19416738
schema:publication	Antiviral Research
resource representing a document's body	covid:5d80f69f6ea60aef7c258bcab7dd4b997c19c24d#body_text
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