About: Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

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About: Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity
Creator	Chou, Kuo-Chen Jiang, Li Chen, Fuxue Du, Dongshu Du, Pu Niu, Bing Qin, Rui Shu, Yilai Su, Qiang Zhang, Mengying
Source	PMC
abstract	Being a neurodegenerative disorder, Alzheimer's disease (AD) is the one of the most terrible diseases. And acetylcholinesterase (AChE) is considered as an important target for treating AD. Acetylcholinesterase inhibitors (AChEI) are considered to be one of the effective drugs for the treatment of AD. The aim of this study is to find a novel potential AChEI as a drug for the treatment of AD. In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking. The findings reported here have provided many useful clues and hints for designing more effective and less toxic drugs against Alzheimer's disease.
has issue date	2017-07-11(xsd:dateTime)
bibo:doi	10.18632/oncotarget.19169
bibo:pmid	28915661
has license	cc-by
sha1sum (hex)	5d9c87ae912ec13a723b6d75bd0ab59618a39164
schema:url	https://doi.org/10.18632/oncotarget.19169
resource representing a document's title	Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity
has PubMed Central identifier	PMC5593632
has PubMed identifier	28915661
schema:publication	Oncotarget
resource representing a document's body	covid:5d9c87ae912ec13a723b6d75bd0ab59618a39164#body_text
is schema:about of	named entity 'absorption spectrometry' named entity 'IMPORTANT' named entity 'HAVE' named entity 'FLUORESCENCE SPECTRA' named entity 'CONSIDERED' named entity 'TO INVESTIGATE' named entity 'NOVEL' named entity 'BEING' named entity 'TOXIC' named entity 'DRUGS' named entity 'INTERACTION' named entity 'MOLECULAR DOCKING' named entity 'USEFUL' named entity 'REPORTED' named entity 'ACETYLCHOLINESTERASE' named entity 'HINTS' named entity 'SPECTROMETRY' named entity 'EXPERIMENTAL' named entity '27S' named entity 'TERRIBLE' named entity 'POTENTIAL' named entity 'EFFECTIVE' named entity 'USING' named entity 'DISEASE' named entity 'USED' named entity 'PLANTS' named entity 'SYNTHETIC' named entity 'DISEASES' named entity 'DRUG' named entity 'AIM' named entity 'MOLECULAR' named entity 'VIS' named entity 'ALZHEIMER' named entity 'ACETYLCHOLINESTERASE INHIBITORS' named entity 'ONE OF' named entity 'NEURODEGENERATIVE DISORDER' named entity 'SMALL' named entity 'MEDICINAL PLANTS' named entity 'DERIVED' named entity 'ACETYLCHOLINESTERASE ACTIVITY' named entity 'TREATMENT' named entity 'ULTRAVIOLET-VISIBLE' named entity 'ABSORPTION' named entity 'TARGET' named entity 'TREATING' named entity 'THEORETICAL' named entity 'CIRCULAR DICHROISM' named entity 'APPROACH' named entity 'APPROACHES' named entity 'EXTRACTED' named entity 'MEANS' named entity 'ACHE' named entity 'FINDINGS' named entity 'STUDY' named entity 'PROVIDED' named entity 'HERE' covid:arg/5d9c87ae912ec13a723b6d75bd0ab59618a39164 named entity 'AChE' named entity 'extracted' named entity 'experimental approach' named entity 'fluorescence' named entity 'acetylcholinesterase' named entity 'absorption spectrometry' named entity 'molecular docking' named entity 'AChEI' named entity 'spectra' named entity 'AChE' named entity 'Small molecular' named entity 'therapeutic strategies' named entity 'red shift' named entity 'emission spectrum' named entity 'AChE'

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