About: One cannot rule them all: Are bacterial toxins-antitoxins druggable?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	One cannot rule them all: Are bacterial toxins-antitoxins druggable?
Creator	Balsa, Dolors Espinosa, Manuel Chan, Wai
Source	Medline; PMC
abstract	Type II (proteic) toxin–antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins constituting a harmless complex. When bacteria encounter a stressful environment, TAs are triggered. The antitoxin protein is unstable and will be degraded by host proteases, releasing the free toxin to halt essential processes. The result is a cessation of cell growth or even death. Because of their ubiquity and the essential processes targeted, TAs have been proposed as good candidates for development of novel antimicrobials. We discuss here the possible druggability of TAs as antivirals and antibacterials, with focus on the potentials and the challenges that their use may find in the ‘real’ world. We present strategies to develop TAs as antibacterials in view of novel technologies, such as the use of very small molecules (fragments) as inhibitors of protein–protein interactions. Appropriate fragments could disrupt the T:A interfaces leading to the release of the targeted TA pair. Possible ways of delivery and formulation of Tas are also discussed.
has issue date	2015-03-21(xsd:dateTime)
bibo:doi	10.1093/femsre/fuv002
bibo:pmid	25796610
has license	cc-by-nc
sha1sum (hex)	5da2c99de592512c4295cc5c1b941e5f6548f065
schema:url	https://doi.org/10.1093/femsre/fuv002
resource representing a document's title	One cannot rule them all: Are bacterial toxins-antitoxins druggable?
has PubMed Central identifier	PMC4487406
has PubMed identifier	25796610
schema:publication	FEMS Microbiol Rev
resource representing a document's body	covid:5da2c99de592512c4295cc5c1b941e5f6548f065#body_text
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