About: Modernising epidemic science: enabling patient-centred research during epidemics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modernising epidemic science: enabling patient-centred research during epidemics
Creator	Horby, Peter Rojek, Amanda
Source	Medline; PMC
abstract	BACKGROUND: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted very quickly. However, patient-centred research is usually not prioritised when planning and enacting the response. Instead, the clinical research response occurs subsequent to and separate from the public health response, and is inadequate for evidence-based decision-making at the bedside or in the offices of public health policymakers. DISCUSSION: The deficiencies of the clinical research response to severe acute respiratory syndrome, pandemic influenza, Middle East respiratory syndrome coronavirus and Ebola virus demonstrate that current research models do not adequately inform and improve the quality of clinical care or public health response. Three suggestions for improvements are made. First, integrate the data and sample collection needs for clinical and public health decision-making within a unified framework, combined with a risk-based, rather than a discipline-based, approach to ethical review and consent. Second, develop clinical study methods and tools that are specifically designed to meet the epidemiological and contextual challenges of emerging and epidemic infectious diseases. Third, invest in investigator-led clinical research networks that are primed and incentivised to respond to outbreak infections, and which can call on the support and resources of a central centre of excellence. CONCLUSIONS: It is crucial that the field of epidemic science matures to place patients at the heart of the response. This can only be achieved when patient-centred research is integrated in the outbreak response from day one and practical steps are taken to reduce the barriers to the generation of reliable and useful evidence.
has issue date	2016-12-19(xsd:dateTime)
bibo:doi	10.1186/s12916-016-0760-x
bibo:pmid	27989237
has license	cc-by
sha1sum (hex)	5dc1559b4274012d8152b7c5f4ca0d637e8b62fa
schema:url	https://doi.org/10.1186/s12916-016-0760-x
resource representing a document's title	Modernising epidemic science: enabling patient-centred research during epidemics
has PubMed Central identifier	PMC5165716
has PubMed identifier	27989237
schema:publication	BMC Med
resource representing a document's body	covid:5dc1559b4274012d8152b7c5f4ca0d637e8b62fa#body_text
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