About: Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9)

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About: Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9)
Creator	Liu, Xiaoli Yuen, Kwok-Yung Zhou, Jie Chen, Yu Wang, Yiyin Yu, Fei Chu, Hin Gao, Hainv Li, Lanjuan Yang, Shigui Zheng, Shufa Li, Cun Yu, Liang Zhu, Yixin Bossé, Yohan Brandsma, Corry-Anke Cheng, Zhongshan Cui, Dawei Fan, Yanhui Hao, Ke Song, You-Qiang Tang, Linglin Bosco, Ho-Yin To, Kai-Wang Wong, Obeidat, Ma9en Sham, Pak
Source	Medline; PMC
abstract	The fatality of avian influenza A(H7N9) infection in humans was over 30%. To identify human genetic susceptibility to A(H7N9) infection, we performed a genome-wide association study (GWAS) involving 102 A(H7N9) patients and 106 heavily-exposed healthy poultry workers, a sample size critically restricted by the small number of human A(H7N9) cases. To tackle the stringent significance cutoff of GWAS, we utilized an artificial imputation program SnipSnip to improve the association signals. In single-SNP analysis, one of the top SNPs was rs13057866 of LGALS1. The artificial imputation (AI) identified three non-genotyped causal variants, which can be represented by three anchor/partner SNP pairs rs13057866/rs9622682 (AI P = 1.81 × 10(−7)), rs4820294/rs2899292 (2.13 × 10(−7)) and rs62236673/rs2899292 (4.25 × 10(−7)) respectively. Haplotype analysis of rs4820294 and rs2899292 could simulate the signal of a causal variant. The rs4820294/rs2899292 haplotype GG, in association with protection from A(H7N9) infection (OR = 0.26, P = 5.92 × 10(−7)) correlated to significantly higher levels of LGALS1 mRNA (P = 0.050) and protein expression (P = 0.025) in lymphoblast cell lines. Additionally, rs4820294 was mapped as an eQTL in human primary monocytes and lung tissues. In conclusion, functional variants of LGALS1 causing the expression variations are contributable to the differential susceptibility to influenza A(H7N9).
has issue date	2015-02-17(xsd:dateTime)
bibo:doi	10.1038/srep08517
bibo:pmid	25687228
has license	cc-by
sha1sum (hex)	5de6f9a65ba8f1857af0057539ff471a4427a157
schema:url	https://doi.org/10.1038/srep08517
resource representing a document's title	Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9)
has PubMed Central identifier	PMC4649671
has PubMed identifier	25687228
schema:publication	Sci Rep
resource representing a document's body	covid:5de6f9a65ba8f1857af0057539ff471a4427a157#body_text
is schema:about of	named entity 'EXPRESSION' named entity 'expression' named entity 'Galectin' named entity 'regulating' named entity 'FUNCTIONAL' named entity 'REGULATING' named entity 'HUMAN' named entity 'SUSCEPTIBILITY' named entity 'LGALS1' named entity 'VARIANTS' named entity 'AFFECT' named entity 'INFLUENZA A' named entity 'infection' named entity 'allele' named entity '0.98' named entity 'H7N9' named entity 'sample size' named entity 'focal adhesion kinase' named entity 'genetic variations' named entity 'LGALS1' named entity 'ECM' named entity 'antiviral activity' named entity 'extracellular matrix' named entity 'odds ratio' named entity 'influenza' named entity 'poultry workers' named entity 'retrovirus' named entity 'H7N9' named entity 'transmembrane receptors' named entity 'eQTL' named entity 'H7N9' named entity 'H7N9' named entity 'rhabdovirus' named entity '2009 pandemic H1N1 influenza' named entity 'haplotype' named entity 'bronchial epithelial cells' named entity 'SNPs' named entity 'viral replication' named entity 'viral replication' named entity 'GENe Expression' named entity 'clinical evidence' named entity 'respiratory tract' named entity 'quality control' named entity 'H5N1' named entity 'inbred' named entity 'H5N1' named entity 'MAPK pathway' named entity 'control group' named entity 'transgenic mice' named entity 'influenza viruses' named entity 'H7N9' named entity 'genetic basis' named entity 'flow cytometry' named entity 'effect size' named entity 'MAPK'

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