About: Hydrocortisone and bronchopulmonary dysplasia: variables associated with response in premature infants

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hydrocortisone and bronchopulmonary dysplasia: variables associated with response in premature infants
Creator	Hanna, Nazeeh Clauss, Christie Khodak, Igor Meredith, • Tack, Valentyna Thomas, • Tiozzo, Caterina
source	PMC
abstract	OBJECTIVE: The primary objective was to evaluate hydrocortisone’s efficacy for decreasing respiratory support in premature infants with developing bronchopulmonary dysplasia (BPD). Secondary objectives included assessment of the impact of intrauterine growth restriction (IUGR), maternal history of chorioamnionitis, side effects and route of administration associated with hydrocortisone’s efficacy. Dexamethasone as second-line treatment to decrease respiratory support was reviewed. METHODS: Retrospective chart review of preterm infants requiring respiratory support receiving hydrocortisone. RESULTS: A total of 48 patients were included. Successful extubation was achieved in 50% of intubated patients after hydrocortisone treatment with no major complications. In our small study, history of maternal chorioamnionitis, IUGR or route of administration did not affect the response. Rescue dexamethasone after hydrocortisone therapy was ineffective in the ten patients who failed extubation following hydrocortisone. CONCLUSION: Hydrocortisone is effective in decreasing respiratory support in patients with developing BPD without major complications. Randomized studies are warranted to confirm our findings.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1038/s41372-020-0680-7
bibo:pmid	32382114
has license	no-cc
sha1sum (hex)	5df431cfd97058a34835a2efc5fe09056024d303
schema:url	https://doi.org/10.1038/s41372-020-0680-7
resource representing a document's title	Hydrocortisone and bronchopulmonary dysplasia: variables associated with response in premature infants
has PubMed Central identifier	PMC7222054
has PubMed identifier	32382114
schema:publication	J Perinatol
resource representing a document's body	covid:5df431cfd97058a34835a2efc5fe09056024d303#body_text
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