About: Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

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About: Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
Creator	Volmer, Romain Marianneau, Philippe Le Goffic, Ronan Picard-Meyer, Evelyne Servat, Alexandre Wasniewski, Marine Lesellier, Sandrine Monchatre-Leroy, Elodie Gouilh, Meriadeg Lacôte, Sandra Bryche, Bertrand Meunier, Nicolas Murri, Severine Pulido, Coralie Rampin, Olivier St Albin, Audrey
Source	BioRxiv; WHO
abstract	Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-19 pandemic. However, the cellular mechanism behind the sudden loss of smell has not yet been investigated. The initial step of odour detection takes place in the pseudostratified olfactory epithelium (OE) mainly composed of olfactory sensory neurons surrounded by supporting cells known as sustentacular cells. The olfactory neurons project their axons to the olfactory bulb in the central nervous system offering a potential pathway for pathogens to enter the central nervous system by bypassing the blood brain barrier. In the present study, we explored the impact of SARS-COV-2 infection on the olfactory system in golden Syrian hamsters. We observed massive damage of the OE as early as 2 days post nasal instillation of SARS-CoV-2, resulting in a major loss of cilia necessary for odour detection. These damages were associated with infection of a large proportion of sustentacular cells but not of olfactory neurons, and we did not detect any presence of the virus in the olfactory bulbs. We observed massive infiltration of immune cells in the OE and lamina propria of infected animals, which may contribute to the desquamation of the OE. The OE was partially restored 14 days post infection. Anosmia observed in COVID-19 patient is therefore likely to be linked to a massive and fast desquamation of the OE following sustentacular cells infection with SARS-CoV-2 and subsequent recruitment of immune cells in the OE and lamina propria.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1101/2020.06.16.151704
has license	biorxiv
sha1sum (hex)	5dfdb63828114fa2d600e510a2ee0f316fdf45d9
schema:url	https://doi.org/10.1101/2020.06.16.151704
resource representing a document's title	Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
schema:publication	bioRxiv
resource representing a document's body	covid:5dfdb63828114fa2d600e510a2ee0f316fdf45d9#body_text
is schema:about of	named entity 'potential' named entity 'pandemic' named entity 'pathogens' named entity 'sustentacular' named entity 'THEIR' named entity 'COMPOSED OF' named entity 'ONE OF' named entity 'THESE' named entity 'INITIAL' named entity 'A MAJOR' named entity 'INSTILLATION' named entity 'AXONS' named entity 'INVESTIGATED' named entity 'SYMPTOMS' named entity 'PROPORTION' named entity 'OLFACTORY BULB' named entity 'PSEUDOSTRATIFIED' named entity 'SURROUNDED BY' named entity 'DETECTION' named entity 'INFECTION' named entity 'ODOUR' named entity 'RESULTING IN' named entity 'MECHANISM' named entity 'GOLDEN' named entity 'ANOSMIA' named entity 'PREVALENT' named entity 'However' named entity 'olfactory sensory neurons' named entity 'infection' named entity 'infection' named entity 'Anosmia' named entity 'blood brain barrier' named entity 'SARS-CoV-2' named entity 'axons' named entity 'COVID-19 pandemic' named entity 'pathogens' named entity 'SARS-CoV-2' named entity 'olfactory sensory neurons' named entity 'Syrian hamsters' named entity 'olfactory epithelium' named entity 'sustentacular cells' named entity 'The' named entity 'olfactory pathway' named entity 'SARS-CoV-1' named entity 'central nervous' named entity 'anosmia' named entity 'SARS-CoV-2' named entity 'lumen' named entity 'immunohistochemistry' named entity 'staining' named entity 'SARS-CoV-1' named entity 'olfactory' named entity 'SARS-CoV-2' named entity 'infection' named entity 'macrophage' named entity 'protease' named entity 'Viral' named entity 'histological' named entity 'Nasopharyngeal' named entity 'epithelium' named entity 'odorants' named entity 'lungs' named entity 'nasal septum' named entity 'lumen' named entity 'desquamated' named entity 'staining' named entity 'lumen' named entity 'SARS-CoV-2' named entity 'nasal cavity'

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