About: Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study

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About: Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study
Creator	Cheifetz, • Duncan, • Fitzgerald, • Gertz, • Hall, • Hsing, • Loomis, • Mahadeo, K Mahadeo, • Mcarthur, • Moffet, J Nitu, • Pinos, • Rowan, • Simmons, • Smith, • Tamburro, • Troy, •
Source	PMC
abstract	In this multicenter study, we investigated the kinetics of neutrophil recovery in relation to acuity and survival among 125 children undergoing allogeneic hematopoietic cell transplantation (allo-HCT) who required invasive mechanical ventilation (IMV). Recovery of neutrophils, whether prior to or after initiation of IMV, was associated with a significantly decreased risk of death relative to never achieving neutrophil recovery. A transient increase in acuity (by oxygenation index and vasopressor requirements) occurred among a subset of the patients who achieved neutrophil recovery after initiation of IMV; 61.5% of these patients survived to discharge from the intensive care unit (ICU). Improved survival among patients who subsequently achieved neutrophil recovery on IMV was not limited to those with peri-engraftment respiratory distress syndrome. The presence of a respiratory pathogen did not affect the risk of death while on IMV but was associated with an increased length of IMV (p < 0.01). Among patients undergoing HCT who develop respiratory failure and require advanced therapeutic support, neutrophil recovery at time of IMV and/or presence of a respiratory pathogen should not be used as determining factors when counseling families about survival.
has issue date	2019-09-16(xsd:dateTime)
bibo:doi	10.1038/s41409-019-0649-3
bibo:pmid	31527817
has license	no-cc
sha1sum (hex)	5e01405d2bef3547be8d95169ef2f4dec01bf181
schema:url	https://doi.org/10.1038/s41409-019-0649-3
resource representing a document's title	Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study
has PubMed Central identifier	PMC7091821
has PubMed identifier	31527817
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:5e01405d2bef3547be8d95169ef2f4dec01bf181#body_text
is schema:about of	named entity 'IMV' named entity 'discharge' named entity 'recovery' named entity 'length' named entity 'survival' named entity 'BUT' named entity 'DEATH' named entity 'SUBSET' named entity 'SURVIVAL' named entity '0.01' named entity 'AFFECT' named entity 'RESPIRATORY' named entity 'INITIATION' named entity 'PERI' named entity '28P' named entity 'LIMITED' named entity 'REQUIRED' named entity 'RESPIRATORY DISTRESS SYNDROME' named entity 'TIME' named entity 'risk' named entity 'prior' named entity 'vasopressor' named entity 'pathogen' named entity 'study' named entity 'Recovery' named entity 'oxygenation' named entity 'patients' named entity 'respiratory distress' named entity 'patients' named entity '0.01' named entity 'risk of death' named entity 'risk of death' named entity 'neutrophil' named entity 'intensive care unit' named entity 'pathogen' named entity 'neutrophil' named entity 'neutrophil' named entity 'neutrophil' named entity 'Acute respiratory failure' named entity 'neutrophil' named entity 'Neutrophil' named entity 'pulmonary infection' named entity 'neutrophils' named entity 'ICU' named entity 'neutrophil' named entity 'ICU' named entity 'neutrophil' named entity 'time-point' named entity 'neutrophil' named entity 'higher risk' named entity 'CPR' named entity 'neutrophils' named entity 'log-rank test' named entity 'pediatric' named entity 'IMV' named entity 'renal replacement therapy' named entity 'inflammatory state' named entity 'RRT' named entity 'IMV' named entity 'ventilator' named entity 'IMV' named entity 'respiratory distress' named entity 'pediatric' named entity 'intubation'

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