About: Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia
Creator	Shetty, Ashok
Source	Medline; PMC
abstract	A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (Leng et al., Aging Dis, 11:216-228, 2020). This study demonstrated that intravenous infusion of MSCs is a safe and effective approach for treating patients with COVID-19 pneumonia, including elderly patients displaying severe pneumonia. COVID-19 is a severe acute respiratory illness caused by a new coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, treating COVID-19 patients, particularly those afflicted with severe pneumonia, is challenging as no specific drugs or vaccines against SARS-CoV-2 are available. Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. Additional studies in a larger cohort of patients are needed to validate this therapeutic intervention further, however.
has issue date	2020-03-09(xsd:dateTime)
bibo:doi	10.14336/ad.2020.0301
bibo:pmid	32257554
has license	cc-by
sha1sum (hex)	5e095761210e537f91067c12ce46f396c0338175
schema:url	https://doi.org/10.14336/ad.2020.0301
resource representing a document's title	Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia
has PubMed Central identifier	PMC7069463
has PubMed identifier	32257554
schema:publication	Aging Dis
resource representing a document's body	covid:5e095761210e537f91067c12ce46f396c0338175#body_text
is schema:about of	named entity 'validate' named entity 'SARS-CoV-2' named entity 'PNEUMONIA' named entity 'CORONAVIRUS' named entity 'FOUND' named entity 'COHORT' named entity 'SPECIFIC' named entity 'REPAIR' named entity 'CURRENTLY' named entity 'SARS-COV-2' named entity 'COVID-19' named entity 'STUDY' named entity 'ENDOGENOUS' named entity 'PROMOTING' named entity 'ADDITIONAL' named entity 'IMPROVING' named entity 'AVAILABLE' named entity 'DRUGS' named entity 'STUDIES' named entity 'THERAPEUTIC INTERVENTION' named entity 'LARGER' named entity 'SEVERE PNEUMONIA' named entity 'PROMISE' named entity 'STRIKING' named entity 'MSC' named entity 'TREATING' named entity 'THERAPY' named entity 'INHIBITING' named entity 'INFUSION' named entity 'VACCINES' named entity 'LUNG' named entity 'INDUCED' named entity 'MESENCHYMAL STEM CELL' named entity 'MICROENVIRONMENT' named entity 'PATIENTS' named entity 'NEEDED' named entity 'IMMUNE SYSTEM' named entity 'Therefore' named entity 'COVID-19' named entity 'COVID-19' named entity 'severe pneumonia' named entity 'COVID-19' named entity 'vaccines' named entity 'COVID-19' named entity 'acute kidney injury' named entity 'infusion' named entity 'intravenous' named entity 'multiple organ dysfunction' named entity 'antiviral' named entity 'RNA-sequencing' named entity 'fibrosis' named entity 'SARS-CoV-2' named entity 'respiratory illness' named entity 'CT imaging' named entity 'COVID' named entity 'number of new cases' named entity 'SARS-CoV-2' named entity 'immune cells' named entity 'respiratory illness' named entity 'TMPRSS2' named entity 'April 2020' named entity 'infection' named entity 'enzyme' named entity 'antiinflammatory' named entity 'Infection' named entity 'pro-inflammatory cytokine' named entity 'shortness of breath' named entity 'lymphocytes' named entity 'epidemic' named entity 'United States' named entity 'body weight' named entity 'CD14' named entity 'pneumonia' named entity 'MSCs' named entity 'COVID' named entity 'TMPRSS2' named entity 'infusion' named entity 'pneumonia' named entity 'high fever' named entity 'MSCs' named entity 'COVID'

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