About: Nervous System Involvement in COVID-19: Results from a Retrospective Consecutive Neuroimaging Cohort

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nervous System Involvement in COVID-19: Results from a Retrospective Consecutive Neuroimaging Cohort
Creator	Al-Saadi, Jonathan Almqvist, Håkan Aspelin, Åsa Finnsson, Johannes Granberg, Tobias Haghgou, Mansour Hasselberg, Mikael Kits, Annika Klironomos, Stefanos Kollia, Evangelia Lundberg, Johan Martin, Heather Ouellette, Russell Pedersen, Mitra Petersson, Sven Tzortzakakis, Antonios Ahoromazdae, ; Delgado, Anna
source	Medline; PMC
abstract	BACKGROUND: Neurological complications in coronavirus disease 2019 (COVID-19) have been described, but the understanding of their pathophysiology and neuroanatomical correlates remains limited. PURPOSE: To report on the frequency and type of neuroradiological findings in COVID-19. MATERIALS AND METHODS: In this retrospective study, all consecutive adult hospitalized patients with PCR-positivity for SARS-CoV-2, undergoing neuroimaging at Karolinska University Hospital between March 2 and May 24, 2020, were included. All examinations were systematically re-evaluated by 12 readers. Summary descriptive statistics were calculated. RESULTS: 185 patients with COVID-19 (62±14 years, 138 men) underwent neuroimaging. In total, 222 brain CT, 47 brain MRI and 7 spinal MRI scans were performed. Intra-axial susceptibility abnormalities were the most common finding (29 of 39 [74%, 95%-CI 58–87%]) in patients with brain MRI, often with an ovoid shape suggestive of microvascular pathology, and with a predilection to corpus callosum (23 of 39, [59%, 95%-CI 42–74%]) and juxtacortical areas (14 of 39, [36%, 95% CI 21-53%]). Ischemic and macrohemorrhagic manifestations were also seen, but vascular imaging did not reveal overt abnormalities. Dynamic susceptibility contrast perfusion MRI in 19 patients did not reveal consistent asymmetries between hemispheres or regions. Many patients (18 of 41 [44%, 95%-CI 28–60%]) had leukoencephalopathy and one patient had a cytotoxic lesion of the corpus callosum. Other findings included olfactory bulb signal abnormalities (7 of 37, 19%), prominent optic nerve subarachnoid spaces (20 of 36, 56%), and enhancement of the parenchyma (3 of 20, 15%), leptomeninges (3 of 20, 15%), cranial nerves (2 of 20, 10%), and spinal nerves (2 of 4, 50%). At MRI follow-up, regression of leukoencephalopathy and progressive leptomeningeal enhancement was observed in one patient respectively, suggestive of dynamic processes. CONCLUSION: Patients with COVID-19 had a wide spectrum of vascular and inflammatory involvement of both the central and peripheral nervous system.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1148/radiol.2020202791
bibo:pmid	32729812
has license	no-cc
sha1sum (hex)	5e147895318cd51797f1bba9417452d8ef3fda07
schema:url	https://doi.org/10.1148/radiol.2020202791
resource representing a document's title	Nervous System Involvement in COVID-19: Results from a Retrospective Consecutive Neuroimaging Cohort
has PubMed Central identifier	PMC7393954
has PubMed identifier	32729812
schema:publication	Radiology
resource representing a document's body	covid:5e147895318cd51797f1bba9417452d8ef3fda07#body_text
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