About: Identification of a contemporary human parechovirus type 1 by VIDISCA and characterisation of its full genome

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About: Identification of a contemporary human parechovirus type 1 by VIDISCA and characterisation of its full genome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a contemporary human parechovirus type 1 by VIDISCA and characterisation of its full genome
Creator	Drosten, Christian Baumgarte, Sigrid Grywna, Klaus Panning, Marcus Drexler, Jan Kleber, Luciano Luna, Souza
Source	Medline; PMC
abstract	BACKGROUND: Enteritis is caused by a spectrum of viruses that is most likely not fully characterised. When testing stool samples by cell culture, virus isolates are sometimes obtained which cannot be typed by current methods. In this study we used VIDISCA, a virus identification method which has not yet been widely applied, on such an untyped virus isolate. RESULTS: We found a human parechovirus (HPeV) type 1 (strain designation: BNI-788st). Because genomes of contemporary HPeV1 were not available, we determined its complete genome sequence. We found that the novel strain was likely the result of recombination between structural protein genes of an ancestor of contemporary HPeV1 strains and nonstructural protein genes from an unknown ancestor, most closely related to HPeV3. In contrast to the non-structural protein genes of other HPeV prototype strains, the non-structural protein genes of BNI-788st and HPeV3 prototype strains did not co-segregate in bootscan analysis with that of other prototype strains. CONCLUSION: HPeV3 nonstructural protein genes may form a distinct element in a pool of circulating HPeV non-structural protein genes. More research into the complex HPeV evolution is required to connect virus ecology with disease patterns in humans.
has issue date	2008-02-12(xsd:dateTime)
bibo:doi	10.1186/1743-422x-5-26
bibo:pmid	18269761
has license	cc-by
sha1sum (hex)	5e2457559eab2f9b131de9084d5dfc66bd875aee
schema:url	https://doi.org/10.1186/1743-422x-5-26
resource representing a document's title	Identification of a contemporary human parechovirus type 1 by VIDISCA and characterisation of its full genome
has PubMed Central identifier	PMC2270820
has PubMed identifier	18269761
schema:publication	Virol J
resource representing a document's body	covid:5e2457559eab2f9b131de9084d5dfc66bd875aee#body_text
is schema:about of	named entity 'JOURNAL ' named entity 'When' named entity 'Virology Journal' named entity 'METHODS' named entity 'TESTING' named entity 'SAMPLES' named entity 'CAUSED BY' named entity 'SPECTRUM' named entity 'ENTERITIS' named entity 'METHOD' named entity 'USED' named entity 'OBTAINED' named entity 'APPLIED' named entity 'CURRENT' named entity 'STUDY' named entity 'GENOME' covid:arg/5e2457559eab2f9b131de9084d5dfc66bd875aee named entity 'HUMAN PARECHOVIRUS TYPE 1' named entity 'VIROLOGY' named entity 'IDENTIFICATION' named entity 'ISOLATE' named entity 'VIRUS' named entity 'CELL CULTURE' named entity 'VIRUSES' named entity 'STOOL' named entity 'ITS' named entity 'BACKGROUND' named entity 'FULLY' named entity 'ISOLATES' named entity 'MOST LIKELY' named entity 'VIRUS IDENTIFICATION' named entity 'virus' named entity 'samples' named entity 'current' named entity 'virus' named entity 'VP1' named entity 'genome' named entity 'model Figure' named entity 'cDNA library' named entity 'initiation codon' named entity 'picornaviruses' named entity 'Phylogenetic analyses' named entity 'Virus' named entity 'stem-loops' named entity 'model Figure' named entity 'protein' named entity 'BLAST search' named entity 'viruses' named entity 'primers' named entity 'protease' named entity 'supernatant' named entity 'type 1' named entity 'human herpesvirus' named entity 'Amino acid' named entity 'virus' named entity 'type 1' named entity 'picornaviruses' named entity 'VP1' named entity 'internal ribosome entry site' named entity 'cell culture' named entity 'nucleotide' named entity 'Enteritis' named entity '1, 2' named entity 'Norovirus' named entity 'structural protein' named entity 'type 1' named entity '300 nM' named entity 'secondary structure' named entity 'VP3' named entity 'structural protein' named entity 'recombination' named entity 'genus' named entity 'primers' named entity 'phylogenetic' named entity 'Karlsruhe'

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