About: Inhibition of Influenza H7 Hemagglutinin-Mediated Entry

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of Influenza H7 Hemagglutinin-Mediated Entry
Creator	Antanasijevic, Aleksandar Caffrey, Michael Cheng, Han Rong, Lijun Wardrop, Duncan
source	Medline; PMC
abstract	The recent outbreak of H7N9 influenza in China is of high concern to public health. H7 hemagglutinin (HA) plays a critical role in influenza entry and thus HA presents an attractive target for antivirals. Previous studies have suggested that the small molecule tert-butyl hydroquinone (TBHQ) inhibits the entry of influenza H3 HA by binding to the stem loop of HA and stabilizing the neutral pH conformation of HA, thereby disrupting the membrane fusion step. Based on amino acid sequence, structure and immunogenicity, H7 is a related Group 2 HA. In this work we show, using a pseudovirus entry assay, that TBHQ inhibits H7 HA-mediated entry, as well as H3 HA-mediated entry, with an IC50∼6 µM. Using NMR, we show that TBHQ binds to the H7 stem loop region. STD NMR experiments indicate that the aromatic ring of TBHQ makes extensive contact with the H7 HA surface. Limited proteolysis experiments indicate that TBHQ inhibits influenza entry by stabilizing the H7 HA neutral pH conformation. Together, this work suggests that the stem loop region of H7 HA is an attractive target for therapeutic intervention and that TBHQ, which is a widely used food preservative, is a promising lead compound.
has issue date	2013-10-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0076363
bibo:pmid	24194835
has license	cc-by
sha1sum (hex)	5e3a5143a77a6faeb480c65a23137616c14e7bad
schema:url	https://doi.org/10.1371/journal.pone.0076363
resource representing a document's title	Inhibition of Influenza H7 Hemagglutinin-Mediated Entry
has PubMed Central identifier	PMC3806803
has PubMed identifier	24194835
schema:publication	PLoS One
resource representing a document's body	covid:5e3a5143a77a6faeb480c65a23137616c14e7bad#body_text
is schema:about of	named entity 'TBHQ' named entity 'structure' named entity 'therapeutic intervention' covid:arg/5e3a5143a77a6faeb480c65a23137616c14e7bad named entity 'OUTBREAK' named entity 'CONFORMATION' named entity 'IS A' named entity 'MEDIATED' named entity 'HIGH' named entity 'EXPERIMENTS' named entity 'HAVE' named entity 'STUDIES' named entity 'CONCERN' named entity 'BINDING' named entity 'MEMBRANE FUSION' named entity 'IC50' named entity 'PUBLIC HEALTH' named entity 'SMALL MOLECULE' named entity 'LEAD COMPOUND' named entity 'AMINO ACID SEQUENCE' named entity 'INFLUENZA' named entity 'THERAPEUTIC INTERVENTION' named entity 'RECENT' named entity 'H7N9 INFLUENZA' named entity 'ENTRY' named entity 'NEUTRAL PH' named entity 'SURFACE' named entity 'LIMITED PROTEOLYSIS' named entity 'GROUP 2' named entity 'RELATED' named entity 'TBHQ' named entity 'EXTENSIVE' named entity 'AROMATIC RING' named entity 'USED' named entity 'ANTIVIRALS' named entity 'IMMUNOGENICITY' named entity 'STRUCTURE' named entity 'STEM LOOP' named entity 'INFLUENZA' named entity 'TARGET' named entity 'STEP' named entity 'BASED' named entity 'PREVIOUS' named entity 'MEDIATED' named entity 'H7 HEMAGGLUTININ' named entity 'PLAYS' named entity 'STD' named entity 'ATTRACTIVE' named entity 'USING' named entity 'PSEUDOVIRUS ENTRY ASSAY' named entity 'WORK' named entity 'ENTRY' named entity 'DISRUPTING' named entity 'ROLE' named entity 'H7 HEMAGGLUTININ' named entity 'INHIBITION' named entity 'STABILIZING' named entity 'PRESENTS' named entity 'TERT-BUTYL' named entity '2C6' named entity 'CONTACT WITH' named entity 'CHINA' named entity 'FOOD PRESERVATIVE' named entity 'CRITICAL' named entity 'NMR' named entity 'HYDROQUINONE' named entity 'stem loop' named entity 'hemagglutinin' named entity 'small molecule' named entity 'TBHQ' named entity 'Group 2' named entity 'tert-butyl' named entity 'immunogenicity' named entity 'public health' named entity 'conformation' named entity 'TBHQ' named entity 'experiments'

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