About: Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein

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About: Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein
Creator	Schwegmann-Weßels, Christel Trincone, Anna
Source	Elsevier; Medline; PMC
abstract	Abstract The spike protein S of transmissible gastroenteritis virus, an Alphacoronavirus, contains a tyrosine-based sorting signal that is responsible for ERGIC retention and may be important for a correct viral assembly process. To find out whether the S protein interacts with cellular proteins via this sorting signal, a pulldown assay with GST fusion proteins was performed. Filamin A has been identified as a putative interaction candidate. Immunofluorescence assays confirmed a co-localization between the TGEV S protein and filamin A. Further experiments have to be performed to prove a significant impact of filamin A on TGEV infection. Different approaches of several researchers for the identification of cellular interaction candidates relevant for coronavirus replication are summarized. These results may help in the future to identify the role of cellular proteins during coronavirus assembly at the ER-Golgi intermediate compartment.
has issue date	2015-04-16(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.11.029
bibo:pmid	25481285
has license	els-covid
sha1sum (hex)	5e3b8a59567c0045414b537628e4c9854f1b6565
schema:url	https://doi.org/10.1016/j.virusres.2014.11.029
resource representing a document's title	Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein
has PubMed Central identifier	PMC7114463
has PubMed identifier	25481285
schema:publication	Virus Research
resource representing a document's body	covid:5e3b8a59567c0045414b537628e4c9854f1b6565#body_text
is schema:about of	named entity 'S PROTEIN' named entity 'PROTEINS' named entity 'Filamin A' named entity 'candidate' named entity 'experiments' named entity 'TGEV' named entity 'TYROSINE' named entity 'SIGNAL' named entity 'ASSAY' named entity 'PULLDOWN' named entity 'VIRAL ASSEMBLY' named entity 'TO IDENTIFY' named entity 'FILAMIN A' named entity 'BASED' named entity 'DIFFERENT' named entity 'CO-LOCALIZATION' named entity 'TYROSINE' named entity 'HAYSTACK' named entity 'SIGNAL' covid:arg/5e3b8a59567c0045414b537628e4c9854f1b6565 named entity 'CORRECT' named entity 'RESULTS' named entity 'FUSION' named entity 'CANDIDATE' named entity 'ER-GOLGI INTERMEDIATE COMPARTMENT' named entity 'ALPHACORONAVIRUS' named entity 'ROLE' named entity 'SIGNIFICANT' named entity 'CELLULAR' named entity 'INTERACT' named entity 'NEEDLE' named entity 'BASED' named entity 'HELP' named entity 'ASSEMBLY' named entity 'APPROACHES' named entity 'RESPONSIBLE' named entity 'CELLULAR' named entity 'LOOKING' named entity 'SORTING' named entity 'IMPACT' named entity 'RETENTION' named entity 'IDENTIFICATION' named entity 'PROTEINS' named entity 'PERFORMED' named entity 'EXPERIMENTS' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'S PROTEIN' named entity 'RELEVANT' named entity 'CONFIRMED' named entity 'INFECTION' named entity 'IDENTIFIED' named entity 'ERGIC' named entity 'GST' named entity 'CONTAINS' named entity 'THESE' named entity 'SPIKE PROTEIN' named entity 'IMPORTANT' named entity 'PROTEIN S' named entity 'SORTING' named entity 'FUTURE' named entity 'PROTEIN ' named entity 'RESEARCHERS' named entity 'INTERACTION' named entity 'MAY BE' named entity 'PROCESS' named entity 'HAVE' named entity 'CORONAVIRUS' named entity 'Immunofluorescence' named entity 'retention' named entity 'gastroenteritis' named entity 'fusion proteins' named entity 'Further' named entity 'Filamin' named entity 'Alphacoronavirus' named entity 'significant impact' named entity 'sorting signal' named entity 'tyrosine' named entity 'protein' named entity 'fusion proteins' named entity 'sorting signal'

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