About: Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein
Creator	Jackwood, Mark Jordan, Brian Leyson, M Lora, Christina
Source	Elsevier; Medline; PMC
abstract	Infectious bronchitis virus is an important respiratory pathogen in chickens. The IBV S1 spike is a viral structural protein that is responsible for attachment to host receptors and is a major target for neutralizing antibodies. To date, there is no experimentally determined structure for the IBV S1 spike. In this study, we sought to find a predicted tertiary structure for IBV S1 using I-TASSER, which is an automated homology modeling platform. We found that the predicted structures obtained were robust and consistent with experimental data. For instance, we observed that all four residues (38, 43, 63, and 68) that have been shown to be critical for binding to host tissues, were found at the surface of the predicted structure of Massachusetts (Mass) S1 spike. Together with antigenicity index analysis, we were also able to show that Ma5 vaccine has higher antigenicity indices at residues close to the receptor-binding region than M41 vaccine, thereby providing a possible mechanism on how Ma5 achieves better protection against challenge. Examination of the predicted structure of the Arkansas IBV S1 spike also gave insights on the effect of polymorphisms at position 43 on the surface availability of receptor binding residues. This study showcases advancements in protein structure prediction and contributes useful, inexpensive tools to provide insights into the biology of IBV.
has issue date	2016-11-09(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2016.11.006
bibo:pmid	27836775
has license	no-cc
sha1sum (hex)	5e6e7aa2ed1dcbfb1a68c659eae0721921d3a28d
schema:url	https://doi.org/10.1016/j.meegid.2016.11.006
resource representing a document's title	Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein
has PubMed Central identifier	PMC7106061
has PubMed identifier	27836775
schema:publication	Infect Genet Evol
resource representing a document's body	covid:5e6e7aa2ed1dcbfb1a68c659eae0721921d3a28d#body_text
is schema:about of	named entity 'protein structure prediction' named entity 'IBV' named entity 'receptors' named entity 'vaccine' named entity 'IBV' named entity 'responsible' named entity 'polymorphisms' named entity 'host' named entity 'predictions' named entity 'infectious bronchitis' covid:arg/5e6e7aa2ed1dcbfb1a68c659eae0721921d3a28d named entity 'predicted' named entity 'tools' named entity 'Infectious bronchitis virus' named entity 'homology modeling' named entity 'spike' named entity 'experimentally' named entity 'surface' named entity 'Massachusetts' named entity 'Examination' named entity 'Insights' named entity 'I-TASSER' named entity 'IBV' named entity 'Infectious bronchitis virus' named entity 'viral structural protein' named entity 'neutralizing antibodies' named entity 'antigenicity' named entity 'polymorphisms' named entity 'antigenicity' named entity 'tertiary structure' named entity 'binding region' named entity 'pathogen' named entity 'Massachusetts' named entity 'infectious bronchitis virus' named entity 'target' named entity 'availability' named entity 'automated' named entity 'host tissues' named entity 'homology modeling' named entity 'glycoprotein' named entity 'experimentally determined' named entity 'receptor' named entity 'protein structure prediction' named entity 'receptor binding' named entity 'molecular structure' named entity 'surface' named entity 'tissues' named entity 'showcases' named entity 'residues' named entity 'data' named entity 'M41' named entity 'residues' named entity 'predicted' named entity 'residues' named entity 'spike' named entity 'For' named entity 'predicted' named entity 'determined' named entity 'position' named entity 'antigenicity' named entity 'IBV' named entity 'chickens' named entity 'instance' named entity 'robust' named entity 'experimental' named entity 'spike' named entity 'tertiary structure' named entity 'Mass' named entity 'glycoprotein' named entity 'pathogen' named entity 'neutralizing antibodies' named entity 'close' named entity 'host' named entity 'provide' named entity 'IBV' named entity 'spike' named entity 'receptor' named entity 'I-TASSER'

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