About: Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments

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About: Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Creator	Baric, Ralph Debbink, Kari Menachery, Vineet
Source	Elsevier; Medline; PMC
abstract	The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of NSP16, a 2′O-methyl-transferase (2′O-MTase), in CoV infection and the host immune response. The review highlights conserved motifs, required interaction partners, as well as the attenuation of NSP16 mutants, and restoration of these mutants in specific immune knockouts. Importantly, the work also identifies a number of approaches to exploit this understanding for therapeutic treatment and the data clearly illustrate the importance of NSP16 2′O-MTase activity for CoV infection and pathogenesis.
has issue date	2014-12-01(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.09.009
bibo:pmid	25278144
has license	bronze-oa
sha1sum (hex)	5e9dd0eb2722df7090897bc78220afb8b09d7f38
schema:url	https://doi.org/10.1016/j.virusres.2014.09.009
resource representing a document's title	Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
has PubMed Central identifier	PMC4260984
has PubMed identifier	25278144
schema:publication	Virus Research
resource representing a document's body	covid:5e9dd0eb2722df7090897bc78220afb8b09d7f38#body_text
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