About: Intense Co-Circulation of Non-Influenza Respiratory Viruses during the First Wave of Pandemic Influenza pH1N1/2009: A Cohort Study in Reunion Island

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About: Intense Co-Circulation of Non-Influenza Respiratory Viruses during the First Wave of Pandemic Influenza pH1N1/2009: A Cohort Study in Reunion Island Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intense Co-Circulation of Non-Influenza Respiratory Viruses during the First Wave of Pandemic Influenza pH1N1/2009: A Cohort Study in Reunion Island
Creator	Carrat, Fabrice Temmam, Sarah Flahault, Antoine Dellagi, Koussay Pascalis, Hervé De Lamballerie, Xavier Rollot, Olivier Turpin, Magali Gé Rardin, Patrick
source	Medline; PMC
abstract	OBJECTIVE: The aim of the present study was to weigh up, at the community level, the respective roles played by pandemic Influenza (pH1N1) virus and co-circulating human Non-Influenza Respiratory Viruses (NIRVs) during the first wave of the 2009 pH1N1 pandemic. METHODS: A population-based prospective cohort study was conducted in Reunion Island during the austral winter 2009 (weeks 30–44) that allowed identification of 125 households with at least one member who developed symptoms of Influenza-like illness (ILI). Three consecutive nasal swabs were collected from each household member (443 individuals) on day 0, 3 and 8 post-ILI report and tested for pH1N1 and 15 NIRVs by RT-PCR. RESULTS: Two successive waves of viral infections were identified: a first wave (W33–37) when pH1N1 was dominant and co-circulated with NIRVs, sharply interrupted by a second wave (W38–44), almost exclusively composed of NIRVs, mainly human Rhinoviruses (hRV) and Coronaviruses (hCoV). Data suggest that some interference may occur between NIRVs and pH1N1 when they co-circulate within the same household, where NIRVs were more likely to infect pH1N1 negative individuals than pH1N1 positive peers (relative risk: 3.13, 95% CI: 1.80–5.46, P<0.001). Viral shedding was significantly shorter (P = 0.035) in patients who were co-infected by pH1N1 and NIRV or by two different NIRVs compared to those who were infected with only one virus, whatever this virus was (pH1N1 or NIRVs). Although intense co-circulation of NIRVs (especially hRV) likely brought pH1N1 under the detection threshold, it did not prevent spread of the pandemic Influenza virus within the susceptible population nor induction of an extensive herd immunity to it. CONCLUSION: Our results suggest that NIRV co-infections during Influenza epidemics may act as cofactors that contribute to shape an outbreak and modulate the attack rate. They further warrant broad spectrum studies to fully understand viral epidemics.
has issue date	2012-09-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0044755
bibo:pmid	22984554
has license	cc-by
sha1sum (hex)	5eb90019b82d03c01d91fd62ca9ba89d60814f82
schema:url	https://doi.org/10.1371/journal.pone.0044755
resource representing a document's title	Intense Co-Circulation of Non-Influenza Respiratory Viruses during the First Wave of Pandemic Influenza pH1N1/2009: A Cohort Study in Reunion Island
has PubMed Central identifier	PMC3440351
has PubMed identifier	22984554
schema:publication	PLoS One
resource representing a document's body	covid:5eb90019b82d03c01d91fd62ca9ba89d60814f82#body_text
is schema:about of	named entity 'INFLUENZA' named entity 'COHORT STUDY' named entity 'REUNION ISLAND' covid:arg/5eb90019b82d03c01d91fd62ca9ba89d60814f82 named entity 'CIRCULATING' named entity 'RESPIRATORY VIRUSES' named entity 'COMMUNITY LEVEL' named entity 'ROLES' named entity 'OBJECTIVE' named entity 'PRESENT' named entity 'INFLUENZA' named entity 'WEIGH' named entity 'NON-' named entity 'HUMAN' named entity 'NON-' named entity 'WAVE' named entity 'PLAYED' named entity 'WAVE' named entity 'INTENSE' named entity 'PANDEMIC' named entity 'RESPIRATORY VIRUSES' named entity 'AIM' named entity 'STUDY' named entity 'VIRUS' named entity 'CIRCULATION' named entity 'PANDEMIC' named entity 'Influenza' named entity '2009' named entity 'pandemic Influenza' named entity 'Viruses' named entity 'Pandemic Influenza' named entity 'ILI' named entity 'W34' named entity 'tested positive' named entity 'pH1N1' named entity 'infection' named entity 'Statistical significance' named entity 'viral shedding' named entity 'murine' named entity '10.4' named entity 'epidemic' named entity 'cohort study' named entity 'ILI' named entity 'virus' named entity 'Reunion Island' named entity 'serologic' named entity 'hRV' named entity 'coinfections' named entity 'pH1N1' named entity 'URTI' named entity 'nasal swab' named entity 'innate immunity' named entity '1, 2' named entity 'epidemic' named entity 'pH1N1' named entity 'plasmid' named entity 'pH1N1' named entity 'Reunion Island' named entity 'viruses' named entity 'virus' named entity 'epidemic' named entity 'pathogen' named entity 'fever' named entity 'pH1N1' named entity 'humidity' named entity 'pH1N1' named entity 'URTI' named entity 'pH1N1' named entity 'viruses' named entity 'epidemic' named entity 'viral shedding' named entity 'Reunion Island' named entity 'fever'

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