About: Marburg Virus Angola Infection of Rhesus Macaques: Pathogenesis and Treatment with Recombinant Nematode Anticoagulant Protein c2

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About: Marburg Virus Angola Infection of Rhesus Macaques: Pathogenesis and Treatment with Recombinant Nematode Anticoagulant Protein c2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Marburg Virus Angola Infection of Rhesus Macaques: Pathogenesis and Treatment with Recombinant Nematode Anticoagulant Protein c2
Creator	Formenty, Pierre Hensley, Lisa Daddario-Dicaprio, Kathleen Fritz, Elizabeth Geisbert, Joan Geisbert, Thomas Young, Howard Larsen, Tom
topic	covid:5ef5b4e66ee425de6c47c148d6609604b6e75a4f#this
Source	Medline; PMC
abstract	Background. The procoagulant tissue factor (TF) is thought to play a role in the coagulation disorders that characterize filoviral infections. In this study, we evaluated the pathogenesis of lethal infection with the Angola strain of Marburg virus (MARV-Ang) in rhesus macaques and tested the efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2), an inhibitor of TF/factor VIIa, as a potential treatment. Methods. Twelve rhesus macaques were challenged with a high dose (1000 pfu) of MARV-Ang. Six macaques were treated with rNAPc2, and 6 macaques served as control animals. Results. All 6 control animals succumbed to MARV-Ang challenge by day 8 (mean, 7.3 days), whereas 5 of 6 rNAPc2-treated animals died on day 9 and 1 rNAPc2-treated animal survived. The disease course for MARVAng infection appeared to progress more rapidly in rhesus macaques than has been previously reported for other strains of MARV. In contrast to Ebola virus (EBOV) infection in macaques, up-regulation of TF was not as striking, and deposition of fibrin was a less prominent pathologic feature of disease in these animals. Conclusions. These data show that the pathogenicity of MARV-Ang infection appears to be consistent with the apparent increased human virulence attributed to this strain. The apparent reduced efficacy of rNAPc2 against MARV-Ang infection, compared with its efficacy against EBOV infection, appears to be associated with differences in TF induction and fibrin deposition.
has issue date	2007-11-15(xsd:dateTime)
bibo:doi	10.1086/520608
bibo:pmid	17940973
has license	no-cc
sha1sum (hex)	5ef5b4e66ee425de6c47c148d6609604b6e75a4f
schema:url	https://doi.org/10.1086/520608
resource representing a document's title	Marburg Virus Angola Infection of Rhesus Macaques: Pathogenesis and Treatment with Recombinant Nematode Anticoagulant Protein c2
has PubMed Central identifier	PMC7110112
has PubMed identifier	17940973
schema:publication	J Infect Dis
resource representing a document's body	covid:5ef5b4e66ee425de6c47c148d6609604b6e75a4f#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/5ef5b4e66ee425de6c47c148d6609604b6e75a4f
is schema:about of	named entity 'MARBURG VIRUS ' named entity 'Recombinant' named entity 'RHESUS MACAQUES' named entity 'TREATMENT' named entity 'PATHOGENESIS' named entity 'INFECTION' named entity 'ANGOLA' named entity 'RECOMBINANT NEMATODE ANTICOAGULANT PROTEIN C2' named entity 'Nematode' named entity 'Recombinant' named entity 'chemokines' named entity 'lymphopenia' named entity 'IL-7' named entity 'serum' named entity 'IL-5' named entity 'total bilirubin' named entity 'Phosphor' named entity 'staining' named entity 'organ' named entity 'Hematology' named entity 'protein' named entity 'organ' named entity 'Atlanta' named entity 'plasma levels' named entity 'alanine aminotransferase' named entity 'Vero cells' named entity 'macaques' named entity 'WBCs' named entity 'body weight' named entity 'Hematology' named entity 'tissue factor' named entity 'MCP-1' named entity 'cortical' named entity 'virulence' named entity 'aspartate aminotransferase' named entity 'experimental control' named entity 'protein' named entity 'macaques' named entity 'd-dimers' named entity 'intramuscular injection' named entity 'fibrin' named entity 'IFN-g' named entity 'coagulopathy' named entity 'virulence' named entity 'infection' named entity 'cell tropism' named entity 'MCP-1' named entity 'Angola' named entity 'IL-10' named entity 'necrosis' named entity 'ZEBOV' named entity 'chemokine' named entity 'ZEBOV' named entity 'eotaxin' named entity 'infection' named entity 'titration' named entity 'rhesus macaque' named entity 'macaques' named entity 'statistically significant' named entity 'RANTES' named entity 'PBMCs' named entity 'Lymphopenia' named entity 'IL-12p40' named entity 'ZEBOV' named entity 'liver' named entity 'rhesus macaques' named entity 'macaques' named entity 'nonhuman primates' named entity 'Flow cytometry' named entity 'coagulation disorders' named entity 'alkaline phosphatase' named entity 'IL-6'

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