About: Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections

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About: Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections
Creator	Id, Benoit, Visseaux Hannet, Irene Jozić, Robert Lisby, Jan Parčina, Marijo Vest Schneider, Uffe
Source	Medline; PMC
abstract	Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. The QIAstat Respiratory Panel(®) assay (QIAstat RP) is a multiplexed in vitro diagnostics test for the rapid simultaneous detection of 21 pathogens directly from respiratory samples, including human mastadenovirus A-G, primate bocaparvovirus 1+2, human coronavirus (HKU1, NL63, OC43, 229E), human metapneumovirus A/B, rhinovirus/enterovirus, influenza A virus (no subtype, subtype H1, H1N1/2009, H3), influenza B virus, human respirovirus 1+3, human orthorubulavirus 2+4, human orthopneumovirus, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. We describe the first multicenter study of 445 respiratory samples, collected through the 2016–2017 and 2018 respiratory seasons, with performance compared against BioFire FilmArray RP v1.7 and discrepancy testing by Seegene Allplex RP. The QIAstat RP demonstrated a positive percentage of agreement of 98.0% (95% CI: 96.0–99.1%) and a negative percentage agreement of 99.8% (95% CI: 99.6–99.9%). With use of this comprehensive and rapid test, improved patient outcomes and antimicrobial stewardship may potentially be achieved.
has issue date	2020-03-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0230183
bibo:pmid	32163484
has license	cc-by
sha1sum (hex)	5f01b0d40881b98c5bcac7aadb11eb27ad25b92a
schema:url	https://doi.org/10.1371/journal.pone.0230183
resource representing a document's title	Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections
has PubMed Central identifier	PMC7067435
has PubMed identifier	32163484
schema:publication	PLoS One
resource representing a document's body	covid:5f01b0d40881b98c5bcac7aadb11eb27ad25b92a#body_text
is schema:about of	named entity '2018' named entity 'multicenter' named entity 'coronavirus' named entity 'OC43' named entity 'viral' named entity 'human' named entity 'diagnosis' named entity 'RAPID' named entity 'PHARYNGITIS' named entity 'CAUSED BY' named entity 'MEDICAL CARE' named entity 'HIGH' named entity 'HUMAN ORTHOPNEUMOVIRUS' named entity '2FB' named entity 'LEGIONELLA PNEUMOPHILA' named entity '2B4' named entity 'ASSAY' named entity 'EVALUATION' named entity 'PCR' named entity 'COMPREHENSIVE' named entity 'MYCOPLASMA PNEUMONIAE' named entity 'DETECTION' named entity 'LIKELY' named entity 'DISCREPANCY' named entity 'ASSAY' named entity 'RAPID' named entity 'EMPIRIC' named entity 'HUMAN CORONAVIRUS' named entity 'ANTIMICROBIAL STEWARDSHIP' named entity 'PATIENTS' named entity 'DIAGNOSIS' named entity 'SIMILAR' named entity 'DIAGNOSTICS TEST' named entity 'PANEL' named entity 'SIMULTANEOUS' named entity '2B2' named entity 'KEY' named entity 'FOR DIAGNOSIS' named entity 'RESPIRATORY' named entity 'COUNTRIES' named entity 'COMPARED' named entity 'COMMON' named entity '99.9' named entity 'ANTIBIOTIC' named entity 'IS A' named entity 'MULTICENTER STUDY' named entity 'ACUTE' named entity 'NEW' named entity 'HIGHLY' named entity 'PANEL' named entity 'INAPPROPRIATE' named entity 'POSITIVE' named entity 'RESULT' named entity 'H1N1' named entity 'BACTERIA.' named entity 'PNEUMONIA' named entity 'HUMAN MASTADENOVIRUS A' named entity 'HUMAN RESPIROVIRUS 1' named entity 'SYMPTOMS' named entity 'INFLUENZA A VIRUS' named entity 'BORDETELLA PERTUSSIS' named entity 'COMMON COLD' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PRESCRIBING' named entity 'PERFORMANCE' named entity 'TESTING' named entity '229E' named entity 'IMPROVED' named entity 'DIFFICULT' named entity 'OC43' named entity 'IN VITRO DIAGNOSTICS' named entity 'ESTIMATED' named entity 'SUBTYPE' named entity 'SETTINGS' named entity 'CHLAMYDIA PNEUMONIAE'

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