About: Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting
Creator	Brierley, Ian Watson, J Manktelow, Emily Shigemoto, Kazuhiro Reith, P Stott, C
topic	covid:5f04dc1178c4d83e7f673119faa173daf1d19394#this
Source	Medline; PMC
abstract	The ribosomal frameshifting signal of the mouse embryonal carcinoma differentiation regulated (Edr) gene represents the sole documented example of programmed −1 frameshifting in mammalian cellular genes [Shigemoto,K., Brennan,J., Walls,E,. Watson,C.J., Stott,D., Rigby,P.W. and Reith,A.D. (2001), Nucleic Acids Res., 29, 4079–4088]. Here, we have employed site-directed mutagenesis and RNA structure probing to characterize the Edr signal. We began by confirming the functionality and magnitude of the signal and the role of a GGGAAAC motif as the slippery sequence. Subsequently, we derived a model of the Edr stimulatory RNA and assessed its similarity to those stimulatory RNAs found at viral frameshift sites. We found that the structure is an RNA pseudoknot possessing features typical of retroviral frameshifter pseudoknots. From these experiments, we conclude that the Edr signal and by inference, the human orthologue PEG10, do not represent a novel ‘cellular class’ of programmed −1 ribosomal frameshift signal, but rather are similar to viral examples, albeit with some interesting features. The similarity to viral frameshift signals may complicate the design of antiviral therapies that target the frameshift process.
has issue date	2005-03-14(xsd:dateTime)
bibo:doi	10.1093/nar/gki299
bibo:pmid	15767280
has license	no-cc
sha1sum (hex)	5f04dc1178c4d83e7f673119faa173daf1d19394
schema:url	https://doi.org/10.1093/nar/gki299
resource representing a document's title	Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting
has PubMed Central identifier	PMC1065257
has PubMed identifier	15767280
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:5f04dc1178c4d83e7f673119faa173daf1d19394#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/5f04dc1178c4d83e7f673119faa173daf1d19394
is schema:about of	named entity 'structure' named entity 'EXAMPLE' named entity 'EDR' named entity 'DO NOT' named entity 'RNA STRUCTURE' named entity 'DOCUMENTED' named entity 'SIMILARITY' named entity 'PSEUDOKNOT' named entity 'SOLE' named entity 'DESIGN' named entity 'BUT' named entity 'FUNCTIONALITY' named entity 'FOUND' named entity 'RES' named entity 'REPRESENT' named entity 'DERIVED' named entity 'STRUCTURE' named entity 'ORTHOLOGUE' named entity 'RETROVIRAL' named entity 'INTERESTING' named entity 'ITS' named entity 'CLASS' named entity 'PSEUDOKNOTS' named entity 'EXAMPLE' named entity 'SIGNAL' named entity 'MOUSE EMBRYONAL CARCINOMA' named entity 'MAMMALIAN' named entity 'SIGNAL' named entity 'EXPERIMENTS' named entity 'ASSESSED' named entity 'CONCLUDE' named entity 'FRAMESHIFT' named entity 'RIBOSOMAL' named entity 'COMPLICATE' named entity 'TO CHARACTERIZE' named entity 'SEQUENCE' named entity 'PROCESS' named entity 'EMPLOYED' named entity 'RNA' named entity 'CHARACTERIZATION' named entity 'RATHER' named entity 'FRAMESHIFT' named entity 'INFERENCE' named entity 'MAGNITUDE' named entity 'THERAPIES' named entity 'GENE' named entity 'VIRAL' named entity 'CELLULAR' named entity 'TYPICAL' named entity 'REGULATED' named entity 'GENES' named entity 'ANTIVIRAL' named entity 'HUMAN' named entity 'HAVE' named entity 'EDR' named entity 'FEATURES' named entity 'MODEL OF' named entity 'NUCLEIC ACIDS' named entity 'MOTIF' named entity 'SITES' named entity 'ROLE' named entity 'THESE' named entity 'RIBOSOMAL' named entity 'MAMMALIAN' named entity 'NOVEL' named entity 'RIBOSOMAL FRAMESHIFT' named entity 'DIFFERENTIATION' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'PROBING' named entity 'HERE' named entity 'CONFIRMING' named entity 'TARGET' named entity 'structure' named entity 'features'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software