About: Surviving sepsis campaign: research priorities for sepsis and septic shock

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Surviving sepsis campaign: research priorities for sepsis and septic shock
Creator	Martin-Loeches, Ignacio Evans, Laura Jog, Sameer Martin, Greg Rhodes, Andrew Antonelli, Massimo De Backer, Daniel Deutschman, Clifford Ferrer, Ricard Coopersmith, Craig Hellman, Judith Kesecioglu, Jozef Lat, Ishaq Levy, Mitchell Machado, Flavia Nunnally, Mark
source	PMC
abstract	OBJECTIVE: To identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock. DESIGN: A consensus committee of 16 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine was convened at the annual meetings of both societies. Subgroups had teleconference and electronic-based discussion. The entire committee iteratively developed the entire document and recommendations. METHODS: Each committee member independently gave their top five priorities for sepsis research. A total of 88 suggestions (ESM 1 - supplemental table 1) were grouped into categories by the committee co-chairs, leading to the formation of seven subgroups: infection, fluids and vasoactive agents, adjunctive therapy, administration/epidemiology, scoring/identification, post-intensive care unit, and basic/translational science. Each subgroup had teleconferences to go over each priority followed by formal voting within each subgroup. The entire committee also voted on top priorities across all subgroups except for basic/translational science. RESULTS: The Surviving Sepsis Research Committee provides 26 priorities for sepsis and septic shock. Of these, the top six clinical priorities were identified and include the following questions: (1) can targeted/personalized/precision medicine approaches determine which therapies will work for which patients at which times?; (2) what are ideal endpoints for volume resuscitation and how should volume resuscitation be titrated?; (3) should rapid diagnostic tests be implemented in clinical practice?; (4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; (5) what are the predictors of sepsis long-term morbidity and mortality?; and (6) what information identifies organ dysfunction? CONCLUSIONS: While the Surviving Sepsis Campaign guidelines give multiple recommendations on the treatment of sepsis, significant knowledge gaps remain, both in bedside issues directly applicable to clinicians, as well as understanding the fundamental mechanisms underlying the development and progression of sepsis. The priorities identified represent a roadmap for research in sepsis and septic shock. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-018-5175-z) contains supplementary material, which is available to authorized users.
has issue date	2018-07-03(xsd:dateTime)
bibo:doi	10.1007/s00134-018-5175-z
bibo:pmid	29971592
has license	no-cc
sha1sum (hex)	5f88afef6af4205e60180f5dea7b656c866f70a0
schema:url	https://doi.org/10.1007/s00134-018-5175-z
resource representing a document's title	Surviving sepsis campaign: research priorities for sepsis and septic shock
has PubMed Central identifier	PMC7095388
has PubMed identifier	29971592
schema:publication	Intensive Care Med
resource representing a document's body	covid:5f88afef6af4205e60180f5dea7b656c866f70a0#body_text
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