About: Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers

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About: Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
Creator	Hennighausen, Lothar Lee, Hye
Source	BioRxiv; Medline
abstract	ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu et al., 2020), raising the possibility that ACE2 expression is under the control of cytokines through the JAK-STAT pathway. Here we show that Ace2 expression in mammary tissue is induced during pregnancy and lactation, which coincides with the establishment of a candidate enhancer. The prolactin-activated transcription factor STAT5 binds to tandem sites that coincide with activating histone enhancer marks and additional transcription components. The presence of pan JAK-STAT components in mammary alveolar cells and in Type II Pneumocytes combined with the autoregulation of both STAT1 and STAT5 suggests a prominent role of cytokine signaling pathways in cells targeted by SARS-CoV-2.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1101/2020.05.11.089045
bibo:pmid	32511315
has license	biorxiv
sha1sum (hex)	5faebf10727332cc9f91a323e702e58efb744d75
schema:url	https://doi.org/10.1101/2020.05.11.089045
resource representing a document's title	Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
has PubMed identifier	32511315
schema:publication	bioRxiv
resource representing a document's body	covid:5faebf10727332cc9f91a323e702e58efb744d75#body_text
is schema:about of	named entity 'pregnancy' named entity 'SARS-CoV-2' named entity 'STAT5' named entity 'candidate' named entity 'facilitates' named entity 'COMPONENTS' named entity 'NOVEL CORONAVIRUS' named entity 'ACE2' named entity 'CELLS' named entity 'PROMINENT' named entity 'INDUCED' named entity 'PATHWAY' named entity 'CANDIDATE' named entity 'PNEUMOCYTES' named entity 'ACTIVATED' named entity 'ADDITIONAL' named entity 'TANDEM' named entity 'BINDS' named entity 'TMPRSS2' named entity 'expressed' named entity 'binds' named entity 'The presence' named entity 'histone' named entity 'RNA' named entity 'SARS-CoV-2' named entity 'pregnancy' named entity 'STAT5' named entity 'TMPRSS2' named entity 'transcription' named entity 'histone' named entity 'ACE2' named entity 'cytokines' named entity 'ACE2' named entity 'Viral' named entity 'cytokines' named entity 'receptor' named entity 'Ace2' named entity 'transcription factors' named entity 'SARS-CoV-2' named entity 'JAK-STAT pathway' named entity 'high blood pressure' named entity 'JAK-STAT pathway' named entity 'RNA-seq' named entity 'STAT' named entity 'lung' named entity 'cytokines' named entity 'Ace2' named entity 'STAT3' named entity 'STAT5' named entity 'STATs' named entity 'transcriptional' named entity 'pneumocytes' named entity 'STAT' named entity 'STATs' named entity 'Brann' named entity 'epithelial cell' named entity 'Covid' named entity 'MED1' named entity 'scRNA-seq' named entity 'JAK3' named entity 'positive control' named entity 'SARS-CoV-2' named entity 'H3K4me1' named entity 'basal cells' named entity 'human tissues' named entity 'enhancer' named entity 'cytokines' named entity 'liver' named entity 'RNA-seq' named entity 'STAT' named entity 'gene expression' named entity 'TYK2' named entity 'ACE2' named entity 'epithelium' named entity 'cytokines' named entity 'DNA motif' named entity 'STAT1' named entity 'STAT' named entity 'tyrosine kinases' named entity 'STAT5' named entity 'steroid hormones'

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