About: One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

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About: One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells
Creator	Li, Wei Ying, Tianlei Wu, Yanling Feng, Yang Ma, Liying Chen, Weizao Wang, Yanping Dimitrov, Dimiter Kong, Desheng Shao, Jiping Yang, Hongjia
source	Medline; PMC
abstract	Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, generation and characterization of BiKEs which consist of CD16A binding human antibody domains fused through a flexible linker to an engineered one-domain soluble human CD4. In presence of cells expressing HIV-1 envelope glycoproteins (Envs), these BiKEs activated specifically CD16A-expressing Jurkat T cells, degranulated NK cells, induced cytokine production and killed Env-expressing cells. They also effectively mediated killing of chronically and acutely HIV-1 infected T cells by human peripheral blood mononuclear cells. The presumed ability of these CD4-based BiKEs to bind all HIV-1 isolates, their small size and fully human origin, combined with high efficacy suggest their potential for HIV-1 eradication.
has issue date	2017-08-22(xsd:dateTime)
bibo:doi	10.1038/s41598-017-07966-3
bibo:pmid	28831040
has license	cc-by
sha1sum (hex)	5fbed89aaeda377c284ad02fc944fc80571e0cab
schema:url	https://doi.org/10.1038/s41598-017-07966-3
resource representing a document's title	One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells
has PubMed Central identifier	PMC5567353
has PubMed identifier	28831040
schema:publication	Sci Rep
resource representing a document's body	covid:5fbed89aaeda377c284ad02fc944fc80571e0cab#body_text
is schema:about of	named entity 'HIV-1' named entity 'killed' named entity 'activated' named entity 'NK cells' named entity 'generation' named entity 'human' named entity 'fused' named entity 'HIV-1' named entity 'Cells' named entity 'KILLED' named entity 'ABILITY' named entity 'INFECTED' named entity 'CELLS' named entity 'KILLING' named entity 'HIV-1' named entity 'GLYCOPROTEINS' named entity 'KILLING' named entity 'CD16A' named entity 'FUSED' named entity 'BIND' named entity 'FULLY' named entity 'PRESENCE OF CELLS' named entity 'INDUCED' named entity 'SMALL SIZE' named entity 'THESE' named entity 'CHARACTERIZATION' named entity 'REPORT' named entity 'ISOLATES' named entity 'CHRONICALLY' named entity 'ENGINEERED' named entity 'ANTIBODY' named entity 'FUSED TO' named entity 'EFFECTIVE' named entity 'CD4' named entity 'DOMAIN' named entity 'GENERATION' named entity 'HERE' named entity 'ANTIBODY' named entity 'PRESUMED' named entity 'BINDING' named entity 'HUMAN' named entity 'MEDIATED' named entity 'EFFICACY' named entity 'SOLUBLE' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'BASED' named entity 'HUMAN ORIGIN' named entity 'CD4' named entity 'ENV' named entity 'POTENTIAL' named entity 'T CELLS' named entity 'CONSIST' named entity 'ERADICATION' named entity 'NK CELLS' named entity 'BIKES' named entity 'SUGGEST' named entity 'ACTIVATED' named entity 'JURKAT' named entity 'MEDIATES' named entity 'CD16' named entity 'OPEN' named entity 'FLEXIBLE' named entity 'COMBINED' named entity 'DESIGN' named entity 'THEIR' named entity 'HIGH' named entity 'CELLS' named entity 'CYTOKINE PRODUCTION' named entity 'DOMAIN' named entity 'HUMAN' named entity 'INFECTED'

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