About: Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection

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About: Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection
Creator	Lindegardh, Niklas Bergqvist, Yngve Blessborn, Daniel Romsing, Susanne
source	PMC
abstract	BACKGROUND: More parasites are becoming resistant to antimalarial drugs, and in many areas a change in first-line drug treatment is necessary. The aim of the developed assay is to help determine drug use in these areas and also to be a complement to interviewing patients, which will increase reliability of surveys. RESULTS: This assay detects quinine, mefloquine, sulfadoxine, pyrimethamine, lumefantrine, chloroquine and its metabolite desethylchloroquine in a 100-µl dried blood spot. Most of the drugs also have long half-lives that make them detectable at least 7 days after administration. The drugs are extracted from the dried blood spot with sequential extraction (due to the big differences in physicochemical properties), solid-phase extraction is used as sample clean-up and separation is performed with gradient-LC with MS ion-trap detection. CONCLUSION: Detection limits (S/N > 5:1) at 50 ng/ml or better were achieved for all drugs except lumefantrine (200 ng/ml), and thus can be used to determine patient compliance. A major advantage of using the ion-trap MS it that it will be possible to go back into the data and look for other drugs as needed.
has issue date	2010-10-20(xsd:dateTime)
bibo:doi	10.4155/bio.10.147
bibo:pmid	21083492
has license	cc-by
sha1sum (hex)	5fda8a3bed403d1da77ac9b0dc2af6a103ecdc04
schema:url	https://doi.org/10.4155/bio.10.147
resource representing a document's title	Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection
has PubMed Central identifier	PMC7099628
has PubMed identifier	21083492
schema:publication	Bioanalysis
resource representing a document's body	covid:5fda8a3bed403d1da77ac9b0dc2af6a103ecdc04#body_text
is schema:about of	named entity 'endogenous' named entity 'Mahidol University' named entity 'Matrix effects' named entity 'Chr' named entity 'Bracknell' named entity 'Metabolite' named entity 'coagulant' named entity 'ion-trap' named entity '1 ml' named entity 'quinine' named entity 'drug content' named entity 'lipophilic' named entity 'amodiaquine' named entity 'proguanil' named entity 'precipitation' named entity 'tartaric acid' named entity 'blood donors' named entity 'drug intake' named entity '5.00' named entity 'reference sample' named entity '12 weeks' named entity 'trifluoroacetic acid' named entity 'filter paper' named entity 'saliva' named entity 'mass spectrometers' named entity 'methanol' named entity 'hydrophobic' named entity 'detection limit' named entity 'matrix effects' named entity 'HCl' named entity 'Thailand' named entity '37°C' named entity 'soluble in water' named entity 'chloroquine' named entity 'hydrophilic' named entity 'lysis' named entity 'sulfadoxine' named entity 'lipophilic' named entity 'correlation' named entity 'high-throughput screening' named entity 'LC-MS' named entity 'TDM' named entity 'quinine' named entity 'venipuncture' named entity 'quinine' named entity 'Pyr' named entity 'lumefantrine' named entity 'Anopheles' named entity 'methanol' named entity 'detection limit' named entity 'Teddington' named entity 'room temperature' named entity 'screening assay' named entity 'first-line drug' named entity 'room temperature' named entity 'metabolite' named entity 'Filter paper' named entity 'methanol' named entity 'ion-trap' named entity 'ion-trap' named entity 'physicochemical properties' named entity 'quality control' named entity 'Precision and accuracy' named entity 'England' named entity 'tartaric acid' named entity 'chlorophenylbiguanide' named entity 'borosilicate glass' named entity 'organic solvents' named entity 'future science group' named entity 'lysis' named entity 'physicochemical properties' named entity 'TDM' named entity 'Bangkok' named entity 'small amounts' named entity 'hydrophilic' named entity 'quinine' named entity 'methanol' named entity 'solvent'

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