About: Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

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About: Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
Creator	Fan, Angela Fang, Xianyang Hammel, Michal Jia, Wenxu Jiang, Liwei Li, Yangyang Shi, Xuanling Wang, Dongli Wang, Han Wang, Pengfei Wang, Shuying Wang, Xinquan Zhang, Linqi Zhang, Senyan Zhou, Panpan Correspondence, Zhang, Linqi, Zhang
Source	Elsevier; Medline; PMC
abstract	The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (RBD) of the spike (S) glycoprotein. Here, we report a unique epitope and unusual neutralizing mechanism of the isolated human antibody MERS-4. Structurally, MERS-4 approached the RBD from the outside of the RBD-DPP4 binding interface. Such binding resulted in the folding of the β5-β6 loop toward a shallow groove on the RBD interface critical for accommodating DPP4. The key residues for binding are identified through site-directed mutagenesis. Structural modeling revealed that MERS-4 binds to RBD only in the “up” position in the S trimer. Furthermore, MERS-4 demonstrated synergy with several reported antibodies. These results indicate that MERS-4 neutralizes MERS-CoV by indirect rather than direct competition with DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.
has issue date	2018-07-10(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2018.06.041
bibo:pmid	29996104
has license	no-cc
sha1sum (hex)	600075fe895d0f33445a5d6ab7c225cddae40064
schema:url	https://doi.org/10.1016/j.celrep.2018.06.041
resource representing a document's title	Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
has PubMed Central identifier	PMC7104183
has PubMed identifier	29996104
schema:publication	Cell Rep
resource representing a document's body	covid:600075fe895d0f33445a5d6ab7c225cddae40064#body_text
is schema:about of	named entity 'combined' named entity 'competition' named entity 'antibodies' named entity 'binding' named entity 'folding' named entity 'RBD' named entity 'epitope' named entity 'Availability' named entity 'REPORT' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'GLYCOPROTEIN' named entity 'ANTIBODY-MEDIATED NEUTRALIZATION' named entity 'DPP4' named entity 'PROVIDES' named entity 'MERS-COV' named entity 'UNIQUE' named entity 'POSITION' named entity 'MODELING' named entity 'SHALLOW' named entity 'STRUCTURAL' named entity 'MERS' named entity 'EPITOPE' named entity 'KEY' named entity 'GROOVE' named entity 'RECEPTOR' named entity 'BINDING' named entity 'EPITOPE' named entity 'MERS- COV' named entity 'UNIQUE' named entity 'LOOP' named entity 'DOMAIN' named entity 'DOMAIN' named entity 'SOFTWARE' named entity 'DATA' named entity 'ARTICLE' named entity 'STRUCTURAL' named entity 'MERS-COV' named entity 'CELLULAR' named entity 'COMPETITION' named entity 'HERE' named entity 'UNUSUAL' named entity 'ANTIBODIES' named entity 'INDIRECT' named entity 'SUMMARY' named entity 'THESE' named entity 'RBD' named entity 'REVEALED' named entity 'USE OF' named entity 'REPORTED' named entity 'COMBINED' named entity 'INTERFACE' named entity 'BINDING' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'ABSTRACT' named entity 'RATHER' named entity 'CRITICAL' named entity 'ADDITION' named entity 'FOLDING' named entity 'BINDS' named entity 'RESULTS' named entity 'DIRECT' named entity 'INFECTION' named entity 'ANTIBODY' named entity 'DIPEPTIDYL PEPTIDASE 4'

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