About: Sample Pretreatment and Nucleic Acid-Based Detection for Fast Diagnosis Utilizing Microfluidic Systems

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About: Sample Pretreatment and Nucleic Acid-Based Detection for Fast Diagnosis Utilizing Microfluidic Systems Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sample Pretreatment and Nucleic Acid-Based Detection for Fast Diagnosis Utilizing Microfluidic Systems
Creator	Lee, Gwo-Bin Wang, Chih-Hung Wang, Jung-Hao
Source	Medline; PMC
abstract	Recently, micro-electro-mechanical-systems (MEMS) technology and micromachining techniques have enabled miniaturization of biomedical devices and systems. Not only do these techniques facilitate the development of miniaturized instrumentation for biomedical analysis, but they also open a new era for integration of microdevices for performing accurate and sensitive diagnostic assays. A so-called “micro-total-analysis-system”, which integrates sample pretreatment, transport, reaction, and detection on a small chip in an automatic format, can be realized by combining functional microfluidic components manufactured by specific MEMS technologies. Among the promising applications using microfluidic technologies, nucleic acid-based detection has shown considerable potential recently. For instance, micro-polymerase chain reaction chips for rapid DNA amplification have attracted considerable interest. In addition, microfluidic devices for rapid sample pretreatment prior to nucleic acid-based detection have also achieved significant progress in the recent years. In this review paper, microfluidic systems for sample preparation, nucleic acid amplification and detection for fast diagnosis will be reviewed. These microfluidic devices and systems have several advantages over their large-scale counterparts, including lower sample/reagent consumption, lower power consumption, compact size, faster analysis, and lower per unit cost. The development of these microfluidic devices and systems may provide a revolutionary platform technology for fast sample pretreatment and accurate, sensitive diagnosis.
has issue date	2011-12-07(xsd:dateTime)
bibo:doi	10.1007/s10439-011-0473-4
bibo:pmid	22146901
has license	no-cc
sha1sum (hex)	605749cd44d672e8598478af30d7e89be8eb5d2a
schema:url	https://doi.org/10.1007/s10439-011-0473-4
resource representing a document's title	Sample Pretreatment and Nucleic Acid-Based Detection for Fast Diagnosis Utilizing Microfluidic Systems
has PubMed Central identifier	PMC7088154
has PubMed identifier	22146901
schema:publication	Ann Biomed Eng
resource representing a document's body	covid:605749cd44d672e8598478af30d7e89be8eb5d2a#body_text
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