About: Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds

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About: Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds
Creator	Abe, Haruka Chaichoune, Kridsada Hiromoto, Yasuaki Kobayashi, Tomoko Matsuu, Aya Parchariyanon, Sujira Patchimasiri, Tuangthong Ratanakorn, Parntep Saito, Takehiko Shiina, Takashi Suzuki, Shingo
Source	PMC
abstract	Differences in the pathogenicity of genetically closely related H5N1 highly pathogenic avian influenza viruses (HPAIVs) were evaluated in White Leghorn chickens. These viruses varied in the clinical symptoms they induced, including lethality, virus shedding, and replication in host tissues. A comparison of the host responses in the lung, brain, and spleen suggested that the differences in viral replication efficiency were related to the host cytokine response at the early phase of infection, especially variations in the proinflammatory cytokine IL-6. Based on these findings, we inoculated the virus that showed the mildest pathogenicity among the five tested, A/pigeon/Thailand/VSMU-7-NPT/2004, into four breeds of Thai indigenous chicken, Phadu-Hung-Dang (PHD), Chee, Dang, and Luang-Hung-Khao (LHK), to explore effects of genetic background on host response. Among these breeds, Chee, Dang, and LHK showed significantly longer survival times than White Leghorns. Virus shedding from dead Thai indigenous chickens was significantly lower than that from White Leghorns. Although polymorphisms were observed in the Mx and MHC class I genes, there was no significant association between the polymorphisms in these loci and resistance to HPAIV.
has issue date	2016-04-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0153649
bibo:pmid	27078641
has license	cc-by
sha1sum (hex)	60b69719c85b64d84bb0b4621ed53108914aebe8
schema:url	https://doi.org/10.1371/journal.pone.0153649
resource representing a document's title	Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds
has PubMed Central identifier	PMC4841636
has PubMed identifier	27078641
schema:publication	PLoS One
resource representing a document's body	covid:60b69719c85b64d84bb0b4621ed53108914aebe8#body_text
is schema:about of	named entity 'highly' named entity 'chicken' named entity 'indigenous' named entity 'responses' named entity 'phase' named entity 'Virus' named entity 'Avian Influenza' named entity 'Pathogenicity' named entity 'SENSITIVITY' named entity 'DIFFERENT' named entity 'BREEDS' named entity 'CYTOKINE ' named entity 'CLINICAL SYMPTOMS' named entity 'WHITE' named entity 'EFFICIENCY' named entity 'INFLUENZA VIRUSES' named entity 'POLYMORPHISMS' named entity 'RELATED' named entity 'H5N1' named entity 'HUNG' named entity 'VIRUSES' named entity 'VIRUS SHEDDING' named entity 'DANG' named entity 'LOCI' named entity 'EARLY' named entity 'INCLUDING' named entity 'ASSOCIATION' named entity 'EFFECTS' covid:arg/60b69719c85b64d84bb0b4621ed53108914aebe8 named entity 'LUNG' named entity 'THAI' named entity 'LEGHORNS' named entity 'PATHOGENICITY' named entity 'BASED' named entity 'MHC CLASS I GENES' named entity 'TIMES' named entity 'RESISTANCE TO' named entity 'NPT' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS' named entity 'STRAINS' named entity 'SIMILAR' named entity 'THESE' named entity 'RESPONSES' named entity 'TISSUES' named entity 'VARIATIONS' named entity 'VIRAL REPLICATION' named entity 'WHITE LEGHORN' named entity 'SURVIVAL' named entity 'DEAD' named entity 'PATHOGENICITY' named entity 'BREEDS' named entity 'HOST' named entity 'INFECTION' named entity 'GENETIC BACKGROUND' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'TESTED' named entity 'RESPONSE' named entity 'LETHALITY' named entity 'VIRUS' named entity 'IL-6' named entity 'SIGNIFICANT' named entity 'SPLEEN' named entity 'COMPARISON' named entity 'REPLICATION' named entity 'PROINFLAMMATORY CYTOKINE' named entity 'INDIGENOUS' named entity 'INDUCED' named entity 'CHICKENS' named entity 'LOWER' named entity 'BRAIN' named entity 'EVALUATED'

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