About: Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors

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About: Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
Creator	Abrams, Gary Chesney, Margaret Melisko, Michelle Miaskowski, Christine Schumacher, Mark Topp, Kimberly Conley, Yvette Kober, Kord Levine, Jon Paul, Steven
source	Elsevier; Medline; PMC
abstract	Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways. Expression profile analysis found 15 experiments having similar whole-transcriptome profiles of DGE related to neuroinflammation and PIPN. These findings suggest that perturbations in pathways associated with neuroinflammation are found in cancer survivors with PIPN.
has issue date	2019-10-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2019.577019
bibo:pmid	31401418
has license	no-cc
sha1sum (hex)	60b99654d6dc155b28cc6800f12e7434cfd45e68
schema:url	https://doi.org/10.1016/j.jneuroim.2019.577019
resource representing a document's title	Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
has PubMed Central identifier	PMC6788784
has PubMed identifier	31401418
schema:publication	J Neuroimmunol
resource representing a document's body	covid:60b99654d6dc155b28cc6800f12e7434cfd45e68#body_text
is schema:about of	named entity 'PATHWAYS' named entity 'PATHWAY' named entity 'MECHANISMS' named entity 'PERIPHERAL BLOOD' named entity 'PRE-CLINICAL' named entity 'BREAST CANCER' named entity 'INDUCED' named entity 'SUGGEST' named entity 'PERIPHERAL NEUROPATHY' named entity 'INDUCED' named entity 'CANCER SURVIVORS' named entity 'PACLITAXEL' named entity 'EXPRESSION PROFILE' named entity 'CHRONIC' named entity 'FOUND' named entity 'TRANSCRIPTOME' named entity 'ASSOCIATED WITH' named entity 'THESE' named entity 'NEUROINFLAMMATION' named entity 'EVALUATED' named entity 'A COMMON' named entity 'HERE' named entity 'ANALYSIS' named entity 'IS A' named entity 'BREAST CANCER' named entity 'PERIPHERAL NEUROPATHY' named entity 'PATHWAYS' named entity '28NI' named entity 'CLINICAL STUDIES' named entity 'ASSOCIATED WITH' named entity 'SIMILAR' named entity 'SIGNALING PATHWAYS' named entity 'EXPERIMENTS' named entity 'DGE' named entity 'CANCER SURVIVORS' named entity 'RELATED' named entity 'DRUG' named entity 'FINDINGS' named entity 'IMPACT' named entity 'DIFFERENTIAL GENE EXPRESSION' named entity 'PACLITAXEL' named entity 'CHEMOTHERAPY' named entity 'IDENTIFIED' named entity 'DEVELOPMENT' covid:arg/60b99654d6dc155b28cc6800f12e7434cfd45e68 named entity 'survivors' named entity 'chemotherapy' named entity 'survivors' named entity 'chemotherapy drug' named entity 'neuroinflammation' named entity 'DGE' named entity 'transcriptome' named entity 'peripheral neuropathy' named entity 'breast cancer' named entity 'peripheral neuropathy' named entity 'pro-inflammatory cytokines' named entity 'biological factors' named entity 'mitochondrial dysfunction' named entity 'gene expression' named entity 'IL6' named entity 'peripheral blood' named entity 'NLRP3' named entity 'peripheral blood' named entity 'leptin' named entity 'pre-clinical evidence' named entity 'metabolic rate' named entity 'TGF-β1' named entity 'astrocyte' named entity 'PNS' named entity 'EPA' named entity 'CIPN' named entity 'adhesive'

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