About: Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines
Creator	De Fátima, Maria Montassier, Helio Montassier, Silva Silva, Borzi, Mariana Cintia, Hiromi Ketherson, Rodrigues Lopes, Priscila Moreira, Romeu Okino, Pavani, Caren Santos Fernando, Filipe
source	Medline; PMC
abstract	In this study, we evaluated antibody and cell-mediated immune (CMI) responses in the mucosal and systemic compartments and protection against challenge with a nephropathogenic Brazilian (BR-I) strain of infectious bronchitis virus (IBV) in chickens submitted to a vaccination regime comprising a priming dose of heterologous live attenuated Massachusetts vaccine followed by a booster dose of an experimental homologous inactivated vaccine two weeks later. This immunization protocol elicited significant increases in serum and lachrymal levels of anti-IBV IgG antibodies and upregulated the expression of CMI response genes, such as those encoding CD8β chain and Granzyme homolog A in tracheal and kidney tissues at 3, 7, and 11 days post-infection in the vaccinated chickens. Additionally, vaccinated and challenged chickens showed reduced viral loads and microscopic lesion counts in tracheal and kidney tissues, and their antibody and CMI responses were negatively correlated with viral loads in the trachea and kidney. In conclusion, the combination of live attenuated vaccine containing the Massachusetts strain with a booster dose of an inactivated vaccine, containing a BR-I IBV strain, confers effective protection against infection with nephropathogenic homologous IBV strain because of the induction of consistent memory immune responses mediated by IgG antibodies and TCD8 cells in the mucosal and systemic compartments of chickens submitted to this vaccination regime.
has issue date	2019-03-12(xsd:dateTime)
bibo:doi	10.1292/jvms.18-0065
bibo:pmid	30867350
has license	cc-by-nc-nd
sha1sum (hex)	60cc55d9df1b0ff215bcaefe413b7b6edc5eb182
schema:url	https://doi.org/10.1292/jvms.18-0065
resource representing a document's title	Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines
has PubMed Central identifier	PMC6483904
has PubMed identifier	30867350
schema:publication	J Vet Med Sci
resource representing a document's body	covid:60cc55d9df1b0ff215bcaefe413b7b6edc5eb182#body_text
is schema:about of	named entity 'INFECTION' named entity 'CHAIN' named entity 'LIVE ATTENUATED VACCINE' named entity 'DOSE' named entity 'LATER' named entity 'THEIR' named entity 'ANTIBODIES' named entity 'ANTIBODY' named entity 'CHALLENGE' named entity 'COUNTS' named entity 'EXPRESSION' named entity 'COMPARTMENTS' named entity 'VACCINE' named entity 'STRAIN' named entity 'PROTOCOL' named entity 'BRAZILIAN' named entity 'IMMUNIZATION' named entity 'CD8' named entity 'CONCLUSION' named entity 'UPREGULATED' named entity 'EXPERIMENTAL' named entity 'ATTENUATED' named entity 'HOMOLOGOUS' named entity 'HETEROLOGOUS' named entity 'CHICKENS' named entity 'STUDY' named entity 'VACCINES' named entity 'VIRAL' named entity 'ELICITED' named entity 'VACCINATION' named entity 'PROTECTION' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'PRIMING' named entity 'SUBMITTED' named entity 'TWO WEEKS' named entity 'CELLS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CHICKENS' named entity 'PROTECTION' named entity 'LIVE' named entity 'HOMOLOGOUS' named entity 'STRAIN' named entity 'IMMUNE RESPONSES' named entity 'INACTIVATED' named entity 'RESPONSES' named entity 'INCREASES' named entity 'ENCODING' named entity 'INDUCTION' named entity 'SYSTEMIC' named entity 'REGIME' named entity 'KIDNEY' named entity 'FOLLOWED BY' named entity 'MUCOSAL' named entity 'GRANZYME' named entity 'EVALUATED' named entity 'CELL' named entity 'CORRELATED' named entity 'TRACHEA' named entity 'IMMUNE RESPONSES' named entity 'LIVE' named entity 'REDUCED' named entity 'TRACHEAL' named entity 'MEMORY' named entity 'COMBINING' named entity 'LEVELS' named entity 'IGG' named entity 'BOOSTER' named entity 'POST' named entity 'CONTAINING' named entity 'RESPONSE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software