About: Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management
Creator	Farnaes, Lauge Foley, Jennifer Pong, Alice Wilke, Julianne Bradley, John Cannavino, Christopher Coufal, Nicole Hong, David Loker, Kathleen
source	Elsevier; Medline; PMC
abstract	Abstract Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now targets the most likely pathogen(s), including those that may demonstrate significant antibiotic resistance. Cell-free plasma next-generation sequencing (CFPNGS) was first made available for Pediatric Infectious Diseases physicians in June 1, 2017, to supplement standard-of-care diagnostic techniques. A retrospective chart review was performed for children hospitalized with CAP between June 1, 2017, and January 22, 2018, to evaluate the impact of CFPNGS. We identified 15 hospitalized children with CAP without other underlying medical conditions for whom CFPNGS was performed. CFPNGS identified a pathogen in 13 of 15 (86%) children compared with 47% for those using standard culture and PCR-based methods alone. Changes in antibiotic management were made in 7 of 15 (47%) of children as a result of CFPNGS.
has issue date	2019-06-30(xsd:dateTime)
bibo:doi	10.1016/j.diagmicrobio.2018.12.016
bibo:pmid	30819624
has license	els-covid
sha1sum (hex)	60e89fbf0ec367b4cb53f903aca0f3e4884a6d81
schema:url	https://doi.org/10.1016/j.diagmicrobio.2018.12.016
resource representing a document's title	Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management
has PubMed Central identifier	PMC7125591
has PubMed identifier	30819624
schema:publication	Diagnostic Microbiology and Infectious Disease
resource representing a document's body	covid:60e89fbf0ec367b4cb53f903aca0f3e4884a6d81#body_text
is schema:about of	named entity 'FOR DIAGNOSIS' named entity 'CHILDREN' named entity 'MANAGEMENT' named entity 'FREE' named entity 'PLASMA' named entity 'SEQUENCING' named entity 'CELL' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'pathogen' named entity 'infection' named entity 'Sequencing reads' named entity 'community-acquired' named entity 'radiographic' named entity 'clinical practice' named entity 'electronic medical record' named entity 'blood cultures' named entity 'radiographic' named entity 'pleural' named entity 'co-infection' named entity 'antibiotic' named entity 'cephalosporin' named entity 'genetic disorder' named entity 'infection' named entity 'Plasma' named entity 'Veillonella' named entity 'pathogen' named entity 'Illumina' named entity 'null hypothesis' named entity 'CAP' named entity 'pneumonia' named entity 'molecule' named entity 'empyema' named entity 'CAP' named entity 'Infectious Disease' named entity 'DNA sequencing' named entity 'laboratory processing' named entity 'CAP' named entity 'pediatric hospital' named entity 'pleural effusion' named entity 'pediatric' named entity 'PCV7' named entity 'microorganism' named entity 'upper airway' named entity 'pathogen' named entity 'CAP' named entity 'Sequence alignment' named entity 'antimicrobial therapy' named entity 'methicillin-resistant Staphylococcus aureus' named entity 'pleural effusion' named entity 'bacterial infection' named entity 'Streptococcus pneumoniae' named entity 'DNA extraction' named entity 'pathogen' named entity 'proof of concept' named entity 'MRSA' named entity 'lung' named entity 'staphylococcal' named entity 'IDSA' named entity 'empiric antibiotic' named entity 'microbial' named entity 'Redwood City' named entity 'vancomycin' named entity 'PCR' named entity 'staphylococcal' named entity 'acute pneumonia' named entity 'Parvimonas micra' named entity 'antibiotic therapy' named entity 'MRSA' named entity 'oncologic' named entity 'pneumococcus' named entity 'pneumonia' named entity 'broad-spectrum antibiotics' named entity 'CAP'

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