About: Plasma TNF‐Binding Capacity and Soluble TNF Receptors in Patients with Juvenile Idiopathic Arthritis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plasma TNF‐Binding Capacity and Soluble TNF Receptors in Patients with Juvenile Idiopathic Arthritis
Creator	Thiel, Steffen Astrinidou-Vakaloudi, A Diamanti, I Georgakopoulou, E Hans, Reinholdt Hoffmann, Jürgen Jesper, Ralf Xatzidimitriou, D Xytsas, S
Source	PMC
abstract	Background: Unbalanced production of proinflammatory cytokines may be related to disease progression in rheumatoid arthritis and juvenile idiopathic arthritis (JIA). Within the TNF system, the two agonists, TNF‐α and TNF‐β, also called lymphotoxin‐α (LT), are bound by soluble TNF receptors (sTNFR‐I and ‐II) that act as natural inhibitors of TNF‐induced inflammation. We investigated the plasma levels of sTNFR‐I in parallel with LT‐binding capacity (LTBC) in patients with JIA. Methods: The levels of sTNFR‐I were measured by ELISA (R&D). LTBC was determined by spiking diluted plasma samples with recombinant LT. Detectable LT was measured by an in‐house ELISA measuring unbound LT only. LTBC was expressed in arbitrary units (AUs) as the percentage value of bound LT to added LT. Result: In contrast to previous findings of elevated sTNFR levels in patients with various chronic inflammatory diseases, we found slightly reduced sTNFR‐I levels in JIA patients (n = 123) compared with age‐matched healthy controls (n = 37): 1077 pg/ml (819–2280) versus 1185 pg/ml (625–2303) [median (range)], P = 0015. However, the sTNFR‐I levels correlated positively with the number of active joints, physicians' global assessment and CRP. In contrast, patient LTBC values were elevated compared to healthy controls: 44 AU (36–52) versus 31 AU (13–41), P < 0.0001. Conclusion: Despite overall slightly reduced plasma levels of sTNFR‐I, the capacity to bind TNF was increased in plasma samples from JIA patients. Studies to identify the TNF‐binding substances in plasma are in progress.
has issue date	2008-06-28(xsd:dateTime)
bibo:doi	10.1111/j.0300-9475.2004.01423b.x
has license	no-cc
sha1sum (hex)	60faef52bf6546591f62af9cb4a3a0e3fff99cbb
schema:url	https://doi.org/10.1111/j.0300-9475.2004.01423b.x
resource representing a document's title	Plasma TNF‐Binding Capacity and Soluble TNF Receptors in Patients with Juvenile Idiopathic Arthritis
has PubMed Central identifier	PMC7169560
schema:publication	Scand J Immunol
resource representing a document's body	covid:60faef52bf6546591f62af9cb4a3a0e3fff99cbb#body_text
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