About: Testing the neutral theory of biodiversity with the microbiome dataset from cystic fibrosis patients

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About: Testing the neutral theory of biodiversity with the microbiome dataset from cystic fibrosis patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Testing the neutral theory of biodiversity with the microbiome dataset from cystic fibrosis patients
Creator	Sun, Yang Chen, Ye Huang, Qi Li, Lianwei Luo, Juan Miao, Yinglei Wang, Kunhua Wang, Yaqiang Xia, Shuxian Xia, Yao
Source	Medline; PMC
abstract	Cystic fibrosis (CF) is a hereditary disease that is characterized by defective mucociliary clearance, airway obstruction, chronic infection, and persistent inflammation. Cystic fibrosis pulmonary exacerbation (CFPE) majorly causes the morbidity of CF patients. Although CF has been demonstrated to change the composition of lung microbial community, previous studies have not made efforts to study the differences in the mechanism of assembly and diversity maintenance of lung microbial community in CF patients. In this study, we applied the neutral theory of biodiversity to comparatively investigate the assembly and diversity maintenance of the lung microbial community before and after the antibiotic treatment by reanalyzing the dataset from Fodor et al's study. We found that no one sample in the lung microbial communities of the sputum samples of Exacerbation group, nor those of End-of-treatment group satisfied the predictions of neutral model, suggesting that the neutral-process does not dominate in CF patients before and after antibiotic treatments. By comparing the biodiversity parameter between Exacerbation and End-of-treatment group, we found that the former had the significantly higher biodiversity, but the change in diversity parameter is slight and the P value is close to.05 (P value = .41). Therefore, our second finding is that although CFPE may increase the biodiversity of lung microbial community, the change is not essential.
has issue date	2018-09-14(xsd:dateTime)
bibo:doi	10.1097/md.0000000000012248
bibo:pmid	30212959
has license	cc-by
sha1sum (hex)	61143198570c983e9975d2c20a361749d92396df
schema:url	https://doi.org/10.1097/md.0000000000012248
resource representing a document's title	Testing the neutral theory of biodiversity with the microbiome dataset from cystic fibrosis patients
has PubMed Central identifier	PMC6156045
has PubMed identifier	30212959
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:61143198570c983e9975d2c20a361749d92396df#body_text
is schema:about of	named entity 'assembly' named entity 'lung' named entity 'inflammation' named entity 'Therefore' named entity 'predictions' named entity 'studies' named entity 'defective' named entity 'biodiversity' named entity 'dataset' named entity 'cystic fibrosis' named entity 'MICROBIOME' named entity 'CYSTIC FIBROSIS' named entity 'DEMONSTRATED' named entity 'STUDY' named entity 'OUR' named entity 'CAUSES' named entity 'MICROBIAL' named entity 'HEREDITARY DISEASE' named entity 'PATIENTS' named entity 'AIRWAY OBSTRUCTION' named entity 'P VALUE' named entity 'ASSEMBLY' named entity 'IS A' named entity 'DOES NOT' named entity 'ESSENTIAL' named entity 'INVESTIGATE' named entity 'APPLIED' named entity 'CYSTIC FIBROSIS PULMONARY EXACERBATION' named entity 'NEUTRAL' named entity 'STUDIES' named entity 'SLIGHT' named entity 'NEUTRAL THEORY' named entity 'CHANGE IN' named entity 'DIVERSITY' named entity 'PREDICTIONS' named entity 'GROUP' named entity 'FINDING' named entity 'SAMPLE' named entity 'ANTIBIOTIC' named entity 'COMPARING' named entity 'CLOSE TO' named entity 'ANTIBIOTIC TREATMENT' named entity 'TESTING' named entity 'SECOND' named entity 'COMPOSITION OF LUNG' named entity 'EXACERBATION' named entity 'TREATMENTS' named entity 'MECHANISM' named entity 'MODEL' named entity 'MAINTENANCE' named entity '28P' named entity 'NEUTRAL THEORY' named entity 'CYSTIC FIBROSIS' named entity 'DATASET' named entity 'OF-' named entity 'FOUND' named entity 'CHRONIC INFECTION' named entity 'MICROBIAL COMMUNITY' named entity 'BIODIVERSITY' named entity 'SAMPLES' named entity 'MORBIDITY' named entity 'COMMUNITIES' named entity 'LUNG' named entity 'VALUE' named entity 'BUT' named entity 'HIGHER' named entity 'PARAMETER' named entity 'THE CHANGE' named entity 'TREATMENT GROUP' named entity 'BIODIVERSITY' named entity 'PREVIOUS' named entity 'PERSISTENT INFLAMMATION'

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