About: D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.

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About: D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
Creator	Korber, Bette Santra, Sampa Haynes, Barton Lewis, Mark Shaw, Pamela Acharya, Priyamvada David, Gobeil, Sophie Mansouri, Katayoun Pardi, Norbert Sutherland, Laura Weissman, Drew Alameh, Mohamad-Gabriel Boesler, Labranche, Celia Mcdanal, Charlene Montefiori, C
Source	MedRxiv
abstract	The SARS-CoV-2 Spike protein acquired a D614G mutation early in the COVID-19 pandemic that appears to confer on the virus greater infectivity and now globally is the dominant form of the virus. Certain of the current vaccines entering phase 3 trials are based on the early D614 form of Spike with the goal of eliciting protective neutralizing antibodies. To determine whether D614G mediates neutralization-escape that could compromise vaccine efficacy, sera from Spike-immunized mice, nonhuman primates and humans were evaluated for neutralization of pseudoviruses bearing either D614 or G614 Spike on their surface. In all cases, G614 Spike pseudovirions were moderately more susceptible to neutralization, indicating this is not an escape mutation that would impede current vaccines. Rather, the gain in infectivity provided by D614G came at the cost of making the virus more vulnerable to neutralizing antibodies.
has issue date	2020-07-24(xsd:dateTime)
bibo:doi	10.1101/2020.07.22.20159905
has license	medrxiv
sha1sum (hex)	614e84e3bb93c9a0e3fd54ed5d149d60c5aa5f8d
schema:url	https://doi.org/10.1101/2020.07.22.20159905
resource representing a document's title	D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
resource representing a document's body	covid:614e84e3bb93c9a0e3fd54ed5d149d60c5aa5f8d#body_text
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