About: Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014
Creator	Maurer-Stroh, Sebastian Liu, Edison Alfaro-Ruiz, Luis Arellano-Llamas, Rocío Arriaga Canon, Cristian Cruz-Lagunas, Alfredo Hidalgo-Miranda, Alfredo Romero Có Rdoba, Sandra Rosshandler, Ivan Vega, Rosa Vázquez-Pé Rez, Joel Wong, Christopher Zú Ñiga, Joaquín
source	PMC
abstract	Since the emergence of the pandemic H1N1pdm09 virus in Mexico and California, biannual increases in the number of cases have been detected in Mexico. As observed in previous seasons, pandemic A/H1N1 09 virus was detected in severe cases during the 2011–2012 winter season and finally, during the 2013–2014 winter season it became the most prevalent influenza virus. Molecular and phylogenetic analyses of the whole viral genome are necessary to determine the antigenic and pathogenic characteristics of influenza viruses that cause severe outcomes of the disease. In this paper, we analyzed the evolution, antigenic and genetic drift of Mexican isolates from 2009, at the beginning of the pandemic, to 2014. We found a clear variation of the virus in Mexico from the 2011–2014 season due to different markers and in accordance with previous reports. In this study, we identified 13 novel substitutions with important biological effects, including virulence, T cell epitope presented by MHC and host specificity shift and some others substitutions might have more than one biological function. The systematic monitoring of mutations on whole genome of influenza A pH1N1 (2009) virus circulating at INER in Mexico City might provide valuable information to predict the emergence of new pathogenic influenza virus
has issue date	2017-07-10(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0180419
bibo:pmid	28692701
has license	cc-by
sha1sum (hex)	61810c29377a4573810dc313f4f5d526e7451c0d
schema:url	https://doi.org/10.1371/journal.pone.0180419
resource representing a document's title	Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014
has PubMed Central identifier	PMC5503254
has PubMed identifier	28692701
schema:publication	PLoS One
resource representing a document's body	covid:61810c29377a4573810dc313f4f5d526e7451c0d#body_text
is schema:about of	named entity 'winter' named entity 'H1N1' named entity 'SEASONS' named entity 'MEXICO' named entity 'OBSERVED' named entity 'VIRUS' named entity 'PREVIOUS' named entity 'CASES' named entity 'INFLUENZA A' named entity 'PREVALENT' named entity 'MEXICO' named entity 'FEATURES' named entity 'INCREASES' named entity 'EMERGENCE' named entity 'DETECTED' named entity 'MOLECULAR' named entity 'HAVE' named entity 'CALIFORNIA' named entity 'PANDEMIC' named entity 'WINTER' named entity 'NUMBER OF' named entity 'SEASONS' named entity 'Mexico' named entity 'pandemic' named entity 'California' named entity 'California' named entity 'influenza' named entity 'Mexico' named entity 'previous seasons' named entity 'Mexico' named entity 'H1N1' named entity 'Mexico' named entity 'cases' named entity 'Mexico' named entity 'prevalent' named entity 'number' named entity 'virus' named entity 'Since' named entity 'emergence' named entity 'Mexico' named entity 'detected' named entity 'observed'
is part of of	covid:61810c29377a4573810dc313f4f5d526e7451c0d#body_text Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014 Since the emergence of the pandemic H1N1pdm09 virus in Mexico and California, biannual increases in the number of cases have been detected in Mexico. As observed in previous seasons, pandemic A/H1N1 09 virus was detected in severe cases during the 2011–2012 winter season and finally, during the 2013–2014 winter season it became the most prevalent influenza virus. Molecular and phylogenetic analyses of the whole viral genome are necessary to determine the antigenic and pathogenic characteristics of influenza viruses that cause severe outcomes of the disease. In this paper, we analyzed the evolution, antigenic and genetic drift of Mexican isolates from 2009, at the beginning of the pandemic, to 2014. We found a clear variation of the virus in Mexico from the 2011–2014 season due to different markers and in accordance with previous reports. In this study, we identified 13 novel substitutions with important biological effects, including virulence, T cell epitope presented by MHC and host specificity shift and some others substitutions might have more than one biological function. The systematic monitoring of mutations on whole genome of influenza A pH1N1 (2009) virus circulating at INER in Mexico City might provide valuable information to predict the emergence of new pathogenic influenza virus

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