About: A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis

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About: A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis
Creator	Chorna, Nataliya Godoy-Vitorino, Filipa
Source	Medline; PMC
abstract	The multi-omic integration of microbiota data with metabolomics has gained popularity. This protocol is based on a human multi-omics study, integrating cervicovaginal microbiota, HPV status and neoplasia, with urinary metabolites. Indeed, to understand the biology of the infections and to develop adequate interventions for cervical cancer prevention, studies are needed to characterize in detail the cervical microbiota and understand the systemic metabolome. This article is a detailed protocol for the multi-omic integration of cervical microbiota and urine metabolome to shed light on the systemic effects of cervical dysbioses associated with Human Papillomavirus (HPV) infections. This methods article suggests detailed sample collection and laboratory processes of metabolomics, DNA extraction for microbiota, HPV typing, and the bioinformatic analyses of the data, both to characterize the metabolome, the microbiota, and joint multi-omic analyses, useful for the development of new point-of-care diagnostic tests based on these approaches.
has issue date	2020-04-08(xsd:dateTime)
bibo:doi	10.3390/biomedicines8040081
bibo:pmid	32276347
has license	cc-by
sha1sum (hex)	6190f652430d632f4d19d7fa7030bf2af12b6fae
schema:url	https://doi.org/10.3390/biomedicines8040081
resource representing a document's title	A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis
has PubMed Central identifier	PMC7235793
has PubMed identifier	32276347
schema:publication	Biomedicines
resource representing a document's body	covid:6190f652430d632f4d19d7fa7030bf2af12b6fae#body_text
is schema:about of	named entity 'studies' named entity 'metabolomics' named entity 'based' named entity 'development' named entity 'human' named entity 'Human Papillomavirus' named entity 'Cervical' named entity 'NEOPLASIA' named entity 'METABOLOME' named entity 'NEEDED' named entity 'STATUS' named entity 'LABORATORY' named entity 'metabolites' named entity 'metabolome' named entity 'metabolomics' named entity 'HPV' named entity 'detail' named entity 'infections' named entity 'protocol' named entity 'data' named entity 'needed' named entity 'metabolome' named entity 'microbiota' named entity 'microbiota' named entity 'urine' named entity 'HPV' named entity 'metabolites' named entity 'metabolome' named entity 'Metabolomics' named entity 'Dysbiosis' named entity 'Human Papillomavirus' named entity 'HPV' named entity 'p-Values' named entity 'beta diversity' named entity 'vagina' named entity 'ion source' named entity 'metabolite' named entity 'urine' named entity 'KEGG' named entity 'liquid biopsy' named entity 'derivatization' named entity 'cervical cancer' named entity 'human papillomavirus' named entity '16S rRNA' named entity 'microbiota' named entity 'Netherlands' named entity 'cube root' named entity 'Greengenes' named entity 'open-source' named entity 'metabolic' named entity 'primers' named entity 'viruses' named entity 'PCR' named entity 'SARS-CoV-2' named entity 'PCR' named entity 'HPV' named entity 'Mass spectral' named entity 'metabolite' named entity 'urine' named entity 'risk factor' named entity 'Vortex mixer' named entity 'Metabolomic' named entity 'dysbiosis' named entity 'GC/MS' named entity 'microorganisms' named entity 'Linear discriminant analysis' named entity 'quality control' named entity 'HPV' named entity 'Archaea' named entity 'RNA sequencing' named entity 'GC/MS' named entity 'plastic' named entity 'MetaboAnalyst' named entity 'Caribbean' named entity 'ASCII' named entity 'metabolome' named entity 'biomarker' named entity 'hypervariable region' named entity 'distance matrix' named entity 'microbiome'

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