About: Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes

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About: Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes
Creator	Baker, Patricia Burmeister, Charlotte Leonard-Murali, Shravan Oncol, Ann Susick, Laura Nathanson, S
Source	Medline; PMC
abstract	BACKGROUND: Two conflicting hypotheses as to how breast cancer (BC) accesses the systemic circulation dominated the 20th century and affected surgical treatment. We hypothesized that tumor lymphovascular invasion (LVI) at the primary tumor site favors lymphatic and not blood vessel, capillaries, and systemic metastases (Smets) are dependent upon regional lymph node (RLN) mets. METHODS: Data from BC patients undergoing RLN biopsy was professionally abstracted and maintained in a prospective, precisely managed, single-institution database. Associations of RLN, LVI, and Smets were estimated by univariate and multivariate backward logistic regression models and patient-affiliated demographic, clinicopathologic, treatment type, and molecular marker data. RESULTS: Of 3329 patients, followed 1–22 years (mean 7.8), 463 of 3329 (13.9%) showed LVI, 742 of 3329 (22.3%) had RLN mets, and 262 of 3329 (7.9%) had Smets. Smets occurred in 52 of 252 (21% with LVI+/RLN+); 116 of 2301 (5% with LVI−/RLN−); 65 of 465 (14% with LVI−/RLN+); and 17 of 207 (8% with LVI+/RLN−), p = 0.021 for association between LVI and Smets for RLN+ patients but not for RLN− patients (p = 0.051). Positive RLN, larger tumor size, and higher grade (all p < 0.001) were predictive of Smets by the multivariable model, whereas positive LVI was not. CONCLUSIONS: LVI predicts RLN mets in BC. RLN is critical to Smets from BC, whereas LVI on its own is not. Smets occur significantly more commonly when both LVI and RLN mets occur together. LVI is, thus, likely to be primarily lymphatic invasion, and rarely, blood vessel invasion, supporting the Halsted paradigm. LVI and RLN together predict clinical outcome better than either alone. GRAPHIC ABSTRACT: [Image: see text]
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1245/s10434-020-08904-w
bibo:pmid	32720039
has license	no-cc
sha1sum (hex)	61b388e6fd79ff047e7d1361a86d77c0c9c46e75
schema:url	https://doi.org/10.1245/s10434-020-08904-w
resource representing a document's title	Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes
has PubMed Central identifier	PMC7384564
has PubMed identifier	32720039
schema:publication	Ann Surg Oncol
resource representing a document's body	covid:61b388e6fd79ff047e7d1361a86d77c0c9c46e75#body_text
is schema:about of	named entity 'patients' named entity 'site' named entity 'RLN' named entity 'RLN' named entity 'RLN' named entity 'systemic circulation' named entity 'Results' named entity 'tumor' named entity 'demographic' named entity 'estimated' named entity 'type' named entity 'molecular marker' named entity 'capillaries' named entity 'Nodes' named entity 'capillaries' named entity 'systemic circulation' named entity 'RLN' named entity '21%' named entity 'tumor' named entity 'RLN' named entity 'molecular marker' named entity 'lymphovascular invasion' named entity 'Regional Lymph Nodes' named entity 'Breast Cancer' named entity 'higher grade' named entity 'Blood vessel' named entity 'RLN' named entity 'lumens' named entity 'endothelial cells' named entity 'molecular mechanisms' named entity 'RLN' named entity 'systemic circulation' named entity 'pericytes' named entity 'RLN' named entity 'lymphatic capillaries' named entity 'chemotherapy' named entity 'ASCAP' named entity 'progesterone' named entity 'blood vessel' named entity '3000 BC' named entity 'lymphatics' named entity 'RLN' named entity 'BCs' named entity 'metastasize' named entity 'hematogenous' named entity 'SLN' named entity 'lymphovascular invasion' named entity 'Mastectomy' named entity 'oncologists' named entity 'Nottingham' named entity 'Lymph nodes' named entity 'oncologists' named entity 'lymph nodes' named entity 'tumor cells' named entity 'RLN' named entity 'animal studies' named entity 'RLN' named entity 'systemic circulation' named entity 'metastases' named entity 'lymph node' named entity 'antibodies' named entity 'metastasized' named entity 'tumors' named entity 'RLN' named entity 'interstitial fluid' named entity 'follow-up' named entity 'lymphovascular invasion' named entity 'blood vessels' named entity 'lymphatics' named entity 'intravasation' named entity 'blood stream' named entity 'primary tumor' named entity 'SLN' named entity 'metastasize' named entity 'correlation' named entity 'metastasis'

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