About: Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination

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About: Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination
Creator	Savarin, Carine Yin, Xinghua Puntambekar, Shweta Bergmann, Cornelia Hinton, David Stohlman, Stephen Trapp, Bruce
Source	Medline; PMC
abstract	Neurotropic coronavirus induces an acute encephalomyelitis accompanied by focal areas of demyelination distributed randomly along the spinal column. The initial areas of demyelination increase only slightly after the control of infection. These circumscribed focal lesions are characterized by axonal sparing, myelin ingestion by macrophage/microglia, and glial scars associated with hypertrophic astrocytes, which proliferate at the lesion border. Accelerated virus control in mice lacking the anti‐inflammatory cytokine IL‐10 was associated with limited initial demyelination, but low viral mRNA persistence similar to WT mice and declining antiviral cellular immunity. Nevertheless, lesions exhibited sustained expansion providing a model of dysregulated white matter injury temporally remote from the acute CNS insult. Expanding lesions in the absence of IL‐10 are characterized by sustained microglial activation and partial loss of macrophage/microglia exhibiting an acquired deactivation phenotype. Furthermore, IL‐10 deficiency impaired astrocyte organization into mesh like structures at the lesion borders, but did not prevent astrocyte hypertrophy. The formation of discrete foci of demyelination in IL‐10 sufficient mice correlated with IL‐10 receptor expression exclusively on astrocytes in areas of demyelination suggesting a critical role for IL‐10 signaling to astrocytes in limiting expansion of initial areas of white matter damage. GLIA 2015;63:2106–2120
has issue date	2015-06-30(xsd:dateTime)
bibo:doi	10.1002/glia.22880
bibo:pmid	26132901
has license	cc-by-nc-nd
sha1sum (hex)	622504276a8cd63e834d19f7b3c26ca4c2bbcb40
schema:url	https://doi.org/10.1002/glia.22880
resource representing a document's title	Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination
has PubMed Central identifier	PMC4755156
has PubMed identifier	26132901
schema:publication	Glia
resource representing a document's body	covid:622504276a8cd63e834d19f7b3c26ca4c2bbcb40#body_text
is schema:about of	named entity 'REGULATOR' named entity 'DECLINING' named entity 'ANTIVIRAL' named entity 'DISTRIBUTED' named entity 'ASTROCYTE' named entity 'INFECTION' named entity 'CNS' named entity 'CELLULAR IMMUNITY' named entity 'SPARING' named entity 'ACQUIRED' named entity 'MODEL OF' named entity 'CIRCUMSCRIBED' named entity 'CORONAVIRUS' named entity 'REMOTE FROM' named entity 'IMPAIRED' named entity 'CHARACTERIZED' named entity 'FORMATION' named entity 'GLIAL' named entity 'ASSOCIATED WITH' named entity 'AXONAL' named entity 'BUT' named entity 'PARTIAL LOSS' named entity 'LIMITING' named entity 'DID' named entity 'PREVENT' named entity 'SUSTAINED' named entity 'ROLE' named entity 'SIGNALING' named entity 'IL-10' named entity 'IL-10' named entity 'macrophage' named entity 'The' named entity 'partial' named entity 'lesions' named entity 'DEMYELINATION' named entity 'PHENOTYPE' named entity 'ACCELERATED' named entity 'EXHIBITING' named entity 'INTERLEUKIN-10 ' covid:arg/622504276a8cd63e834d19f7b3c26ca4c2bbcb40 named entity 'BORDER' named entity 'DISCRETE' named entity 'ASTROCYTES' named entity 'HYPERTROPHIC ASTROCYTES' named entity 'IL-10' named entity 'CYTOKINE ' named entity 'INCREASE' named entity 'LESION' named entity 'LOSS OF' named entity 'WHITE MATTER' named entity 'RECEPTOR EXPRESSION' named entity 'LESIONS' named entity 'FOLLOWING' named entity 'WHITE MATTER LESION' named entity 'INDUCED' named entity 'CRITICAL' named entity 'IS A' named entity 'VIRAL' named entity 'INSULT' named entity 'MACROPHAGE' named entity 'VIRUS' named entity 'CONTROL' named entity 'MESH' named entity 'CRITICAL' named entity 'ENCEPHALOMYELITIS' named entity 'ACUTE' named entity 'ABSENCE OF' named entity 'BORDERS' named entity 'WHITE MATTER INJURY' named entity 'SUFFICIENT' named entity 'DAMAGE' named entity 'IL-10 RECEPTOR' named entity 'MICE' named entity 'THESE' named entity 'MYELIN'

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