About: Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing

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About: Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing
Creator	Wang, Lin-Fa Zhu, Feng Irving, Aaron Chionh, Yok Mendenhall, Ian Ng, Justin Chia, Wan Wen, Ming Lee, Y-H
Source	Medline; PMC
abstract	BACKGROUND: In the past two decades, bats have emerged as an important model system to study host-pathogen interactions. More recently, it has been shown that bats may also serve as a new and excellent model to study aging, inflammation, and cancer, among other important biological processes. The cave nectar bat or lesser dawn bat (Eonycteris spelaea) is known to be a reservoir for several viruses and intracellular bacteria. It is widely distributed throughout the tropics and subtropics from India to Southeast Asia and pollinates several plant species, including the culturally and economically important durian in the region. Here, we report the whole-genome and transcriptome sequencing, followed by subsequent de novo assembly, of the E. spelaea genome solely using the Pacific Biosciences (PacBio) long-read sequencing platform. FINDINGS: The newly assembled E. spelaea genome is 1.97 Gb in length and consists of 4,470 sequences with a contig N50 of 8.0 Mb. Identified repeat elements covered 34.65% of the genome, and 20,640 unique protein-coding genes with 39,526 transcripts were annotated. CONCLUSIONS: We demonstrated that the PacBio long-read sequencing platform alone is sufficient to generate a comprehensive de novo assembled genome and transcriptome of an important bat species. These results will provide useful insights and act as a resource to expand our understanding of bat evolution, ecology, physiology, immunology, viral infection, and transmission dynamics.
has issue date	2018-09-20(xsd:dateTime)
bibo:doi	10.1093/gigascience/giy116
bibo:pmid	30247613
has license	cc-by
sha1sum (hex)	628791ab32e8dc2a3e032fdd76f507da5f9ef04b
schema:url	https://doi.org/10.1093/gigascience/giy116
resource representing a document's title	Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing
has PubMed Central identifier	PMC6177735
has PubMed identifier	30247613
schema:publication	Gigascience
resource representing a document's body	covid:628791ab32e8dc2a3e032fdd76f507da5f9ef04b#body_text
is schema:about of	named entity 'generate' named entity 'assembled' named entity 'sequencing' named entity 'repeat' named entity 'India' named entity 'VIRUSES' named entity 'COMPREHENSIVE' named entity 'DURIAN' named entity 'PROVIDE' named entity 'CONTIG N50' named entity 'REPEAT' named entity 'EVOLUTION' named entity 'CONCLUSIONS' named entity 'TROPICS' named entity 'TRANSCRIPTOME SEQUENCING' named entity 'SOUTHEAST ASIA' named entity 'STUDY' named entity 'expand' named entity 'transcriptome' named entity 'demonstrated' named entity 'spelaea' named entity 'provide' named entity 'transmission' named entity 'platform' named entity 'spelaea' named entity 'covered' named entity 'N50' named entity 'durian' named entity 'Southeast Asia' named entity 'spelaea' named entity 'transcriptome' named entity 'cave nectar bat' named entity 'genome' named entity 'transcriptome' named entity 'bat' named entity 'important model' named entity 'subtropics' named entity 'Eonycteris spelaea' named entity 'viruses' named entity 'bat species' named entity 'PacBio' named entity 'genome' named entity 'lesser dawn bat' named entity 'bacteria' named entity 'whole-genome' named entity 'Eonycteris' named entity 'Here' named entity 'reservoir' named entity 'protein coding' named entity 'transcriptome' named entity 'Illumina sequencing' named entity 'bat' named entity 'homologous' named entity 'genomes' named entity 'Genome Biology' named entity 'Korea' named entity 'mRNAs' named entity 'PacBio' named entity 'DNase' named entity 'Eonycteris spelaea' named entity 'million years ago' named entity 'genomic analyses' named entity 'pathogenic viruses' named entity 'bat' named entity 'DNA libraries' named entity 'divergence' named entity 'genomes' named entity 'Genome data' named entity 'widely distributed' named entity 'orthologous genes' named entity 'Illumina' named entity 'PacBio' named entity 'bat'

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