About: Protein-directed ribosomal frameshifting temporally regulates gene expression

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protein-directed ribosomal frameshifting temporally regulates gene expression
Creator	Ling, Roger Brierley, Ian Bell, Susanne Napthine, Sawsan Firth, Andrew Finch, Leanne Jones, Joshua
source	Medline; PMC
abstract	Programmed −1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift −1 nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as trans-acting switches to turn frameshifting on or off in response to cellular conditions. Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activated by viral protein 2A. As a result, the frameshifting efficiency increases from 0 to 70% (one of the highest known in a mammalian system) over the course of infection, temporally regulating the expression levels of the viral structural and enzymatic proteins.
has issue date	2017-06-08(xsd:dateTime)
bibo:doi	10.1038/ncomms15582
bibo:pmid	28593994
has license	cc-by
sha1sum (hex)	62918573a167d69a0056aa9462d5cc1d9ae351fa
schema:url	https://doi.org/10.1038/ncomms15582
resource representing a document's title	Protein-directed ribosomal frameshifting temporally regulates gene expression
has PubMed Central identifier	PMC5472766
has PubMed identifier	28593994
schema:publication	Nat Commun
resource representing a document's body	covid:62918573a167d69a0056aa9462d5cc1d9ae351fa#body_text
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