About: SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends
Creator	Bouzaher, Yanis González-Santamaría, José Rivas, Carmen Seoane, Rocío Vidal, Santiago Bouzaher, Y Motiam, A Motiam, Ahmed Seoane, · Vidal, ·
Source	Medline; PMC
abstract	SUMO is a ubiquitin-like protein that covalently binds to lysine residues of target proteins and regulates many biological processes such as protein subcellular localization or stability, transcription, DNA repair, innate immunity, or antiviral defense. SUMO has a critical role in the signaling pathway governing type I interferon (IFN) production, and among the SUMOylation substrates are many IFN-induced proteins. The overall effect of IFN is increasing global SUMOylation, pointing to SUMO as part of the antiviral stress response. Viral agents have developed different mechanisms to counteract the antiviral activities exerted by SUMO, and some viruses have evolved to exploit the host SUMOylation machinery to modify their own proteins. The exploitation of SUMO has been mainly linked to nuclear replicating viruses due to the predominant nuclear localization of SUMO proteins and enzymes involved in SUMOylation. However, SUMOylation of numerous viral proteins encoded by RNA viruses replicating at the cytoplasm has been lately described. Whether nuclear localization of these viral proteins is required for their SUMOylation is unclear. Here, we summarize the studies on exploitation of SUMOylation by cytoplasmic RNA viruses and discuss about the requirement for nuclear localization of their proteins.
has issue date	2019-12-24(xsd:dateTime)
bibo:doi	10.1007/978-3-030-38266-7_11
bibo:pmid	32274761
has license	no-cc
sha1sum (hex)	62e4c8f98091a5807871324d58b035cf6b016073
schema:url	https://doi.org/10.1007/978-3-030-38266-7_11
resource representing a document's title	SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends
has PubMed Central identifier	PMC7144409
has PubMed identifier	32274761
schema:publication	Proteostasis and Disease
resource representing a document's body	covid:62e4c8f98091a5807871324d58b035cf6b016073#body_text
is schema:about of	named entity 'viral' named entity 'transcription' named entity 'substrates' named entity 'antiviral' named entity 'machinery' named entity 'SUMO' named entity 'SUMOylation' named entity 'involved' named entity 'antiviral' named entity 'Viruses' named entity 'TRANSCRIPTION' named entity 'INCREASING' named entity 'REPLICATING' named entity 'PROTEIN ' named entity 'PREDOMINANT' named entity 'predominant' named entity 'innate' named entity 'proteins' named entity 'viral' named entity 'nuclear localization' named entity 'SUMOylation' named entity 'SUMO' named entity 'RNA' named entity 'SUMOylation' named entity 'nuclear localization' named entity 'immunity' named entity 'Viral' named entity 'SUMO' named entity 'viral proteins' named entity 'lysine' named entity 'SUMOylation' named entity 'protein' named entity 'nuclear localization' named entity 'SUMOylation' named entity 'nuclear localization' named entity 'replicating viruses' named entity 'RNA viruses' named entity 'SUMO' named entity 'type I interferon' named entity 'nuclear localization' named entity 'protein-protein interaction' named entity 'SUMO' named entity 'hantaviruses' named entity 'SUMO' named entity 'NLS' named entity 'RNA-dependent RNA polymerase' named entity 'Nairovirus' named entity 'PTEN' named entity 'VP40' named entity 'SUMOylation' named entity 'reovirus' named entity 'protein' named entity 'type I interferons' named entity 'genus' named entity 'Torovirinae' named entity 'SUMOylation' named entity 'SUMOylation' named entity 'Ubc9' named entity 'nucleocapsid' named entity 'RIG-I' named entity 'nucleolus' named entity 'genus' named entity 'highly conserved' named entity 'SUMOylation' named entity 'SUMOylation' named entity 'SUMO' named entity 'senescence' named entity 'viruses' named entity 'viral proteins' named entity 'SUMOylation' named entity 'SUMOylation' named entity 'hand, foot, and mouth disease'

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