About: The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study
Creator	Ariyoshi, Koya Suzuki, Motoi Abe, Masahiko Aoshima, Masahiro Asoh, Norichika Hamashige, Naohisa Ishifuji, Tomoko Katsurada, Naoko Morimoto, Konosuke Yaegashi, Makito
Source	Medline; PMC
abstract	BACKGROUND: Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS: This multicentre prospective study enrolled pneumonia patients aged ≥15 years from September 2011 to August 2014. Sputum samples were tested by in-house multiplex polymerase chain reaction assays to identify 13 respiratory viruses. Viral infection status and its effect on in-hospital mortality were examined by age group and comorbidity status. RESULTS: A total of 2617 patients were enrolled in the study and 77.8% was aged ≥65 years. 574 (21.9%) did not have comorbidities, 790 (30.2%) had chronic respiratory disease, and 1253 (47.9%) had other comorbidities. Viruses were detected in 605 (23.1%) patients. Human rhinovirus (9.8%) was the most frequently identified virus, followed by influenza A (3.9%) and respiratory syncytial virus (3.9%). Respiratory syncytial virus was more frequently identified in patients with chronic respiratory disease (4.7%) than those with other comorbidities (4.2%) and without comorbidities (2.1%) (p = 0.037). The frequencies of other viruses were almost identical between the three groups. Virus detection overall was not associated with increased mortality (adjusted risk ratio (ARR) 0.76, 95% CI 0.53–1.09). However, influenza virus A and B were associated with three-fold higher mortality in patients with chronic respiratory disease but not with other comorbidities (ARR 3.38, 95% CI 1.54–7.42). Intriguingly, paramyxoviruses were associated with dramatically lower mortality in patients with other comorbidities (ARR 0.10, 95% CI 0.01–0.70) but not with chronic respiratory disease. These effects were not affected by age group. CONCLUSIONS: The impact of virus infections on pneumonia mortality varies by virus type and comorbidity status in adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-017-2858-y) contains supplementary material, which is available to authorized users.
has issue date	2017-12-06(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2858-y
bibo:pmid	29212450
has license	cc-by
sha1sum (hex)	6302e80258b85ac4f27c6db06bcf9e245e981ba9
schema:url	https://doi.org/10.1186/s12879-017-2858-y
resource representing a document's title	The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study
has PubMed Central identifier	PMC5719746
has PubMed identifier	29212450
schema:publication	BMC Infect Dis
resource representing a document's body	covid:6302e80258b85ac4f27c6db06bcf9e245e981ba9#body_text
is schema:about of	named entity 'PNEUMONIA' named entity 'comorbidities' named entity 'stratified' named entity 'OBSERVATIONAL STUDY' named entity 'VIRAL INFECTIONS' named entity 'EFFECT' named entity 'STUDY' named entity 'COMORBIDITIES' named entity 'INFECTIONS' named entity 'IMPACT' named entity 'MORTALITY' named entity 'KNOWN' named entity 'PNEUMONIA' named entity 'MORTALITY' named entity 'COMPLEX' named entity 'PROSPECTIVE' named entity 'ADULT' named entity 'VIRUS INFECTION' named entity 'VIRUSES' named entity 'UNCLEAR' named entity 'BACKGROUND' named entity 'CLARIFY' named entity 'VIRUS TYPE' named entity 'IMPACT' named entity 'PATIENT' named entity 'VIRUS' named entity 'ADULTS' named entity 'ASSOCIATED WITH' named entity 'STRATIFIED' named entity 'VARIOUS' named entity 'ADULTS' covid:arg/6302e80258b85ac4f27c6db06bcf9e245e981ba9 named entity 'clarify' named entity 'adults' named entity 'viruses' named entity 'comorbidities' named entity 'co-infection' named entity 'community-acquired pneumonia' named entity 'virus' named entity 'ageing society' named entity 'interstitial pneumonia' named entity 'comorbidities' named entity 'pneumonia' named entity 'institutional review boards' named entity 'sputum' named entity 'comorbidities' named entity 'pneumonia' named entity 'comorbidities' named entity 'comorbidity' named entity 'risk of death' named entity 'liver disease' named entity 'comorbidities' named entity 'respiratory syncytial virus' named entity 'pneumonia' named entity 'antiviral' named entity 'type 1' named entity 'written consent' named entity 'virus' named entity 'malignancy' named entity 'antibiotic' named entity 'mortality rates' named entity 'pneumonia' named entity 'pneumonia' named entity 'viral infections' named entity 'comorbidities' named entity 'pneumonia' named entity 'viral infection' named entity 'viruses' named entity 'sputum' named entity 'neuromuscular diseases' named entity 'sputum' named entity 'CAP'

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