About: Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients
Creator	Sanguinetti, Maurizio Gasbarrini, Antonio Cingolani, Antonella De Stefano, Valerio Fantoni, Massimo Murri, Rita Bellesi, Silvia Chiusolo, Patrizia D'innocenzo, Simone Ferraironi, Manuela Hohaus, Stefan Maiolo, Elena Marchionni, Federica Metafuni, Elisabetta Ramundo, Francesco Sica, Simona Sorda, Marilena
source	Medline; PMC
abstract	A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the Coronavirus disease 2019 (COVID‐19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD‐1 expression on both CD4+ T and CD8+ T cells in 42 COVID‐19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of Naive events. Our results might suggest a shift to antigen‐activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID‐19 infection.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1111/bjh.17034
bibo:pmid	32679621
has license	no-cc
sha1sum (hex)	63465d7b1cd847fcf6a321f0118a261ea5558bc5
schema:url	https://doi.org/10.1111/bjh.17034
resource representing a document's title	Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients
has PubMed Central identifier	PMC7405050
has PubMed identifier	32679621
schema:publication	Br J Haematol
resource representing a document's body	covid:63465d7b1cd847fcf6a321f0118a261ea5558bc5#body_text
is schema:about of	named entity 'CD95' named entity 'COVID-19' named entity 'CD4+' named entity 'RESULTS' named entity 'IS A' named entity 'SUGGEST' named entity 'exhaustion' named entity 'CD95' named entity 'CD8+' named entity 'count' named entity 'COVID-19' named entity 'CD4+' named entity 'CD4+' named entity 'antigen' named entity 'CD8+' named entity 'CD4+' named entity 'flow cytometry' named entity 'COVID-19' named entity 'PD-1' named entity 'CD8+' named entity 'Fas' named entity 'PERIPHERAL BLOOD' named entity 'apoptosis' named entity 'CD95' named entity 'innate immune response' named entity 'viral pneumonia' named entity 'COVID-19' named entity 'PD-1' named entity 'CD95' named entity 'cytokines' named entity 'Wuhan' named entity 'lymphocytes' named entity 'CD4+' named entity 'CD8+ T cells' named entity 'CD4+' named entity 'COVID' named entity 'CD8' named entity 'COVID-19 infection' named entity 'older age' named entity 'CD8+' named entity 'fever' named entity 'lymphocytes' named entity 'antigen' named entity 'blood sampling' named entity 'CD4+' named entity 'CD4+' named entity 'COVID' named entity 'upper respiratory tract' named entity 'corticosteroids' named entity 'TNF-alfa' named entity 'IL-6' named entity 'peripheral blood' named entity 'antigen' named entity 'lymphocyte count' named entity 'CD4+' named entity 'phenotype' named entity 'infection' named entity 'viral infections' named entity 'adaptive immune responses' named entity 'CD95' named entity 'HIV' named entity 'clinical history' named entity 'statistically significant' named entity 'ARDS' named entity 'CD4'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software