About: Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA)

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About: Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA)
Creator	Markus, Maren Zorn, Eickmann
source	Medline; PMC
abstract	INTRODUCTION: Since the first case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection was reported in 2012, the virus has infected more than 1300 individuals in 26 countries, and caused more than 480 deaths. Human-to-human transmission requires close contact, and has typically occurred in the healthcare setting. Improved global awareness, together with improved hygiene practices in healthcare facilities, has been highlighted as key strategies in controlling the spread of MERS-CoV. This study tested the in vitro efficacy of three formulations of povidone iodine (PVP-I: 4% PVP-I skin cleanser, 7.5% PVP-I surgical scrub, and 1% PVP-I gargle/mouthwash) against a reference virus (Modified vaccinia virus Ankara, MVA) and MERS-CoV. METHODS: According to EN14476, a standard suspension test was used to assess virucidal activity against MVA and large volume plating was used for MERS-CoV. All products were tested under clean (0.3 g/L bovine serum albumin, BSA) and dirty conditions (3.0 g/L BSA + 3.0 mL/L erythrocytes), with application times of 15, 30, and 60 s for MVA, and 15 s for MERS-CoV. The products were tested undiluted, 1:10 and 1:100 diluted against MVA, and undiluted against MERS-CoV. RESULTS: A reduction in virus titer of ≥4 log(10) (corresponding to an inactivation of ≥99.99%) was regarded as evidence of virucidal activity. This was achieved versus MVA and MERS-CoV, under both clean and dirty conditions, within 15 s of application of each undiluted PVP-I product. CONCLUSION: These data indicate that PVP-I-based hand wash products for potentially contaminated skin, and PVP-I gargle/mouthwash for reduction of viral load in the oral cavity and the oropharynx, may help to support hygiene measures to prevent transmission of MERS-CoV. FUNDING: Mundipharma Research GmbH & Co. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-015-0091-9) contains supplementary material, which is available to authorized users.
has issue date	2015-09-28(xsd:dateTime)
bibo:doi	10.1007/s40121-015-0091-9
bibo:pmid	26416214
has license	no-cc
sha1sum (hex)	6394756d9759bedd7e0053f7b99a7df74da7a16a
schema:url	https://doi.org/10.1007/s40121-015-0091-9
resource representing a document's title	Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA)
has PubMed Central identifier	PMC4675768
has PubMed identifier	26416214
schema:publication	Infect Dis Ther
resource representing a document's body	covid:6394756d9759bedd7e0053f7b99a7df74da7a16a#body_text
is schema:about of	named entity 'Vaccinia Virus' named entity 'Introduction' named entity 'Middle East Respiratory Syndrome Coronavirus' named entity 'POVIDONE' named entity 'IODINE PRODUCTS' named entity 'EFFECTIVE' named entity 'INTRODUCTION' named entity 'VACCINIA VIRUS ANKARA' named entity 'CASE' named entity 'RAPID' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ACTIVITY' named entity 'MODIFIED' named entity 'Rapid' named entity 'MERS-CoV' named entity 'enveloped viruses' named entity 'virucidal' named entity 'MERS-CoV' named entity 'sanitizers' named entity 'International Health Regulations' named entity 'viruses' named entity 'mucosal surfaces' named entity 'coronaviruses' named entity 'antiseptic' named entity 'hand hygiene' named entity 'Germany' named entity 'MERS-CoV' named entity 'disinfectant' named entity 'mouthwash' named entity 'coughing' named entity 'hygiene' named entity 'MERS-CoV' named entity 'severe acute respiratory syndrome' named entity 'human population' named entity 'microbe' named entity 'MERS' named entity 'pathogens' named entity 'ethanol' named entity 'cytotoxic' named entity 'respiratory illness' named entity 'index case' named entity 'iodine' named entity 'iodine' named entity 'skin cleanser' named entity 'alcohol-based hand rub' named entity 'colony-forming unit' named entity 'washing hands' named entity 'virucidal' named entity 'Bahrain' named entity 'iodine' named entity 'medical field' named entity 'hand washing' named entity 'viral titers' named entity 'iodine' named entity 'Ebola virus' named entity 'cell culture' named entity 'SARS' named entity 'hand hygiene' named entity 'Republic of Korea' named entity 'povidone iodine' named entity 'hygiene' named entity 'infection' named entity 'norovirus' named entity 'June 2012' named entity 'sneezing' named entity 'antiseptic' named entity 'sanitizers' named entity 'sanitizers' named entity 'viral transmission' named entity 'pharynx' named entity 'Limburg' named entity 'disease outbreak' named entity 'enveloped viruses' named entity 'MERS-CoV' named entity 'Modified vaccinia virus Ankara' named entity 'SARS-CoV' named entity 'feline calicivirus' named entity 'MERS-CoV' named entity 'Saudi Arabia' named entity 'endemic'

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