About: Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model

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About: Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
Creator	Prüfer, Steffen Bodmer, Bianca Fiedler, Anna Hanauer, Jan Mühlebach, Michael
topic	covid:63fbcac09bf2a0133b41cb99e93dd2ce3aeeab05#this
source	Elsevier; Medline; PMC
abstract	Abstract Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MVvac2-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MVvac2-MERS-S(H) or novel MVvac2-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8+ T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MVvac2-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8+ T cells and MV-specific CD4+ T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MVvac2-MERS-S(H) induces multifunctional cellular immunity.
has issue date	2018-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2018.05.028
bibo:pmid	29902727
has license	els-covid
sha1sum (hex)	63fbcac09bf2a0133b41cb99e93dd2ce3aeeab05
schema:url	https://doi.org/10.1016/j.virol.2018.05.028
resource representing a document's title	Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
has PubMed Central identifier	PMC7118890
has PubMed identifier	29902727
schema:publication	Virology
resource representing a document's body	covid:63fbcac09bf2a0133b41cb99e93dd2ce3aeeab05#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/63fbcac09bf2a0133b41cb99e93dd2ce3aeeab05
is schema:about of	named entity 'MEASLES VIRUS' named entity 'vaccines' named entity 'RESPONSES' named entity 'VACCINATION' named entity 'MICE' named entity 'NECESSITY' named entity 'CASES' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CONTINUE' named entity 'ONE OF' named entity 'SIGNIFICANT' named entity 'VACCINE DEVELOPMENT' named entity 'VAC2' named entity 'SUSCEPTIBLE' named entity 'VECTOR' named entity 'MERS' named entity 'DETECTED' named entity 'APPROPRIATE' named entity 'MOUSE MODEL' named entity 'NOVEL' named entity 'LIVE' named entity 'ROBUST' named entity 'T CELL' named entity 'ATTENUATED' named entity 'INDUCE' named entity 'DERIVED' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'VIRUSES' named entity 'CELLULAR IMMUNITY' named entity 'SIMULTANEOUSLY' named entity 'VACCINE CANDIDATE' named entity 'ANTIBODY TITERS' named entity 'CD4' named entity 'MEASLES VIRUS' named entity 'ROBUST' named entity 'IMMUNIZATION' named entity 'PROTECTION' named entity 'FUNCTIONAL' named entity 'TARGETING' named entity 'INDUCED' named entity 'REPLICATION' named entity 'LIVE' named entity 'IFN' named entity 'FRACTION OF' named entity 'CHARACTERIZED' named entity 'SPECIFIC' named entity 'REVEALING' named entity 'VACCINES' named entity 'MEDIATING' named entity 'OCCUR' named entity 'COMPETENT' named entity 'HERE' named entity 'CD8' named entity 'FOCUSED' named entity 'NEUTRALIZING ANTIBODY' named entity 'T CELLS' named entity 'INDUCTION' named entity 'ACCELERATED' named entity 'CLEARANCE' named entity 'VIRUS' named entity 'INACTIVATED' named entity '28H' named entity 'BASED' named entity 'IMMUNITY' named entity 'ADULT' named entity 'TRIGGERED' named entity 'ATTENUATED' named entity 'TARGETS' named entity 'NATURE' named entity 'CONTRIBUTE ' named entity 'ENCODING' named entity 'VACCINE' covid:arg/63fbcac09bf2a0133b41cb99e93dd2ce3aeeab05 named entity 'expressing' named entity 'IFN-γ'

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