About: A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos

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About: A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos
Creator	Gao, Fei Shi, Xuanling Zhang, Linqi Tang, Xiaoping Wang, Ruoke Yin, Chibiao Yu, Lei Zhang, Fuchun Jiang, Yisheng Li, Cui Xu, Zhiheng Correspondence, Linqi, Zhang
Source	Elsevier; Medline; PMC
abstract	Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is generally benign in humans. However, an emergent strain of ZIKV has become widespread, causing severe pre- and post-natal neurological defects. There is now an urgent need for prophylactic and therapeutic agents. To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities. One antibody, ZK2B10, showed the most potent neutralization activity, completely protected uninfected mice, and markedly reduced tissue pathology in infected mice. Thus, ZK2B10 is a promising candidate for the development of antibody-based interventions and informs the rational design of ZIKV vaccine.
has issue date	2018-05-01(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2018.04.005
bibo:pmid	29719255
has license	no-cc
sha1sum (hex)	649d38a5d9193f1070c4c27575c583a46a739e23
schema:url	https://doi.org/10.1016/j.celrep.2018.04.005
resource representing a document's title	A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos
has PubMed Central identifier	PMC7104101
has PubMed identifier	29719255
schema:publication	Cell Rep
resource representing a document's body	covid:649d38a5d9193f1070c4c27575c583a46a739e23#body_text
is schema:about of	named entity 'There' named entity 'vivo' named entity 'pathology' named entity 'mouse' named entity 'tested' named entity 'Thus' named entity 'Highlights' named entity 'antibody' named entity 'Mouse' named entity 'INJECTION' named entity 'TESTED' named entity 'ACTIVITY' named entity 'MOUSE MODELS' named entity 'MICROCEPHALY' named entity 'THESE' named entity 'INFECTED' named entity 'ANTIBODY' named entity 'PROPHYLACTIC' named entity 'THERAPEUTIC AGENTS' named entity 'PRE' named entity 'TRANSMITTED' named entity 'DEVELOPMENT' named entity 'NEUROLOGICAL' named entity 'BENIGN' named entity 'SINGLE' named entity 'MARKEDLY' named entity 'SUMMARY' named entity 'COMPLETELY' named entity 'SEVERE' named entity 'SPECIFICITY' named entity 'VACCINE' named entity 'PROTECTION' named entity 'IN VITRO' named entity 'LEVELS' named entity 'INTERVENTIONS' named entity 'ZIKA VIRUS' named entity 'ADULT' named entity 'UNINFECTED' named entity 'HUMAN' named entity 'SINGLE' named entity 'MONOCLONAL ANTIBODIES' named entity 'INFECTION' named entity 'CAUSING' named entity 'DESIGN' named entity 'PATHOLOGY' named entity 'POST' named entity 'STRAIN' named entity 'MOSQUITO' named entity 'PROVIDES' named entity 'IN UTERO' named entity 'ZIKV' named entity 'WIDESPREAD' named entity 'CANDIDATE' named entity 'MICROCEPHALY' named entity 'ZIKA VIRUS INFECTION' named entity 'NEUTRALIZING ANTIBODY' named entity 'MOUSE' named entity 'EMBRYOS' named entity 'INVESTIGATED' named entity 'TISSUE' named entity 'ACTIVITIES' named entity 'ANTIBODIES' named entity 'IN VIVO' named entity 'FLAVIVIRUS' named entity 'ADDRESS' named entity 'THEIR' named entity 'URGENT' named entity 'BASED' named entity 'MIRRORED'

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