About: Serine Proteases in the Lectin Pathway of the Complement System

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About: Serine Proteases in the Lectin Pathway of the Complement System Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serine Proteases in the Lectin Pathway of the Complement System
Creator	Messias-Reason, Iara Andrade, Fabiana Catarino, Sandra Lidani, Kárita Andrade, F Catarino, • Lidani, • Messias-Reason, I
source	PMC
abstract	The complement system plays a crucial role in host defense against pathogen infections and in the recognition and removal of damaged or altered self-components. Complement system activation can be initiated by three different pathways—classical, alternative, and lectin pathways—resulting in a proteolytic cascade, which culminates in multiple biological processes including opsonization and phagocytosis of intruders, inflammation, cell lysis, and removal of immune complexes and apoptotic cells. Furthermore, it also functions as a link between the innate and adaptive immune responses. The lectin pathway (LP) activation is mediated by serine proteases, termed mannan-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with the pattern recognition molecules (PRMs) that recognize carbohydrates or acetylated compounds on surfaces of pathogens or apoptotic cells. These result in the proteolysis of complement C2 and C4 generating C3 convertase (C4b2a), which carries forward the activation cascade of complements, culminating in the elimination of foreign molecules. This chapter presents an overview of the complement system focusing on the characterization of MASPs and its genes, as well as its functions in the immune response.
has issue date	2017-06-10(xsd:dateTime)
bibo:doi	10.1007/978-981-10-2513-6_18
has license	no-cc
sha1sum (hex)	64fd5dfa6f8374cf052b456770acc1d44275b58d
schema:url	https://doi.org/10.1007/978-981-10-2513-6_18
resource representing a document's title	Serine Proteases in the Lectin Pathway of the Complement System
has PubMed Central identifier	PMC7120406
schema:publication	Proteases in Physiology and Pathology
resource representing a document's body	covid:64fd5dfa6f8374cf052b456770acc1d44275b58d#body_text
is schema:about of	named entity 'complement system' named entity 'This' named entity 'The' named entity 'host defense' named entity 'HOST DEFENSE' named entity 'PLAYS' named entity 'COMPLEMENT SYSTEM' named entity 'CHARACTERIZATION' named entity 'PATHWAYS' named entity 'DAMAGED' named entity 'CARRIES' named entity 'RECOGNIZE' named entity 'THESE' named entity 'IMMUNE COMPLEXES' named entity 'CELL LYSIS' named entity 'INFECTIONS' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'BIOLOGICAL PROCESSES' named entity 'OVERVIEW' named entity 'FOCUSING' named entity 'COMPLEMENT C2' named entity 'FOREIGN' named entity 'SERINE PROTEASES' named entity 'ITS' named entity 'ALTERED' named entity 'COMPLEMENTS' named entity '2C CELL' named entity 'MULTIPLE' named entity 'LINK' named entity 'ASSOCIATED WITH' named entity 'CASCADE' named entity 'PATHOGEN' named entity 'PROTEOLYSIS' named entity 'SERINE PROTEASES' named entity 'MASPS' named entity 'CLASSICAL' named entity 'GENERATING' named entity 'LECTIN PATHWAY' named entity 'DIFFERENT' named entity 'PATTERN RECOGNITION' named entity 'ROLE' named entity 'REMOVAL' named entity 'RESULTING IN' named entity 'CELLS' named entity 'LECTIN' named entity 'APOPTOTIC' named entity 'CARBOHYDRATES' named entity 'INCLUDING' named entity 'FUNCTIONS' named entity 'PRESENTS' named entity 'ELIMINATION' named entity 'COMPLEMENT SYSTEM' named entity 'MOLECULES' named entity 'MEDIATED' named entity 'SURFACES' named entity 'IMMUNE RESPONSE' named entity 'RECOGNITION' named entity 'RESULT' named entity 'CHAPTER' named entity 'PROTEOLYTIC' named entity 'PATHOGENS' named entity 'ACTIVATION' named entity 'OPSONIZATION' named entity 'ALTERNATIVE' named entity 'PHAGOCYTOSIS' named entity 'ACETYLATED' named entity 'GENES' named entity 'INFLAMMATION' named entity 'CULMINATING' named entity 'FORWARD' named entity 'LECTIN PATHWAY' named entity 'MANNAN-BINDING LECTIN' named entity 'proteolytic' named entity 'initiated' named entity 'apoptotic cells' named entity 'apoptotic cells'

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