About: Porcine reproductive and respiratory syndrome virus inhibition of interferon-β transcription by IRF3-independent mechanisms in MARC-145 cells in early infection

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About: Porcine reproductive and respiratory syndrome virus inhibition of interferon-β transcription by IRF3-independent mechanisms in MARC-145 cells in early infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine reproductive and respiratory syndrome virus inhibition of interferon-β transcription by IRF3-independent mechanisms in MARC-145 cells in early infection
Creator	Fang, Weihuan Li, Xiaoliang Zhang, Xian Hu, Hongxia Wen, Guilan Zhang, Hansong Zhang, Qianqian
Source	Elsevier; Medline; PMC
abstract	Abstract Interferon β is an important antiviral molecule whose expression is triggered through recognition of viral components by pattern recognition receptors via a cascade of signaling molecules, while viruses could target these molecules to evade from innate immunity. IFN regulatory factor 3 (IRF3) plays a crucial role in innate immune responses. Here, we demonstrate that PRRSV infection did not induce IFN-β gene transcription in MARC-145 cells, but inhibited poly (I:C) stimulated IFN-β gene transcription instead. Such inhibition is time-dependent with the progression of PRRSV infection. We also show that the inhibition of IFN-β transcription in the early stage of infection could not be due to inhibition of phosphorylation and nuclear translocation of IRF3, though significant decrease of p-IRF3 and its nuclear translocation in PRRSV-infected and poly (I:C) cells was observed later at 48h post-infection. The different patterns of inhibition for IFN-β transcription and IRF3 phosphorylation have important implications as to the mechanism(s) by which PRRSV suppresses the type I IFN signaling at early stage of infection. There could be mechanism(s) other than effecting on IRF3 or molecules upstream that require further investigation.
has issue date	2013-11-15(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2013.09.015
bibo:pmid	24148827
has license	els-covid
sha1sum (hex)	652b5b6c877598793abd57f2dadd3f25021ae115
schema:url	https://doi.org/10.1016/j.vetimm.2013.09.015
resource representing a document's title	Porcine reproductive and respiratory syndrome virus inhibition of interferon-β transcription by IRF3-independent mechanisms in MARC-145 cells in early infection
has PubMed Central identifier	PMC7112902
has PubMed identifier	24148827
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:652b5b6c877598793abd57f2dadd3f25021ae115#body_text
is schema:about of	named entity '90%' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'INFECTION' named entity '28I' named entity 'INFECTION' named entity 'POST' named entity 'INHIBITION' named entity 'PLAYS' named entity 'HAVE' named entity '90%' named entity 'MOLECULES' named entity 'VIRUSES' named entity 'IRF3' named entity 'NUCLEAR TRANSLOCATION' named entity 'POLY' named entity 'COULD BE' named entity 'DEPENDENT' named entity 'STIMULATED' named entity 'TRIGGERED' named entity 'DID' named entity 'INTERFERON' named entity 'INHIBITION' named entity 'MECHANISM' named entity 'PHOSPHORYLATION' named entity '145' named entity 'EARLY' named entity 'TIME' named entity 'ANTIVIRAL' named entity 'MECHANISMS' named entity 'CELLS' named entity 'IRF3' named entity 'MARC' named entity 'MOLECULE' named entity 'EXPRESSION' named entity 'INTERFERON ' named entity 'LATER' named entity 'VIRAL COMPONENTS' named entity 'HERE' named entity 'EARLY STAGE' named entity 'UPSTREAM' named entity 'INHIBITION OF PHOSPHORYLATION' named entity 'INDUCE' named entity 'SUPPRESSES' named entity 'OTHER THAN' named entity 'IMMUNE RESPONSES' named entity 'REGULATORY' named entity 'GENE TRANSCRIPTION' named entity 'SIGNALING' named entity 'INHIBITED' named entity 'EFFECTING' named entity 'OBSERVED' named entity 'FACTOR' named entity 'TARGET' named entity 'DECREASE' named entity 'CELLS' named entity 'ROLE' named entity 'PRRSV' named entity 'INNATE IMMUNITY' named entity '145' named entity '28S' named entity 'INVESTIGATION' named entity 'PROGRESSION' named entity 'THESE' named entity 'CASCADE' named entity 'TYPE I' named entity 'SIGNALING MOLECULES' named entity 'INFECTED' named entity 'RECOGNITION' named entity 'TRANSCRIPTION' named entity 'IFN' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'DIFFERENT' named entity 'ITS' named entity 'BUT' named entity 'INDEPENDENT'

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